Comprehensive evaluation of 68Ga-PSMA-11 PET/CT parameters for discriminating pathological characteristics in primary clear-cell renal cell carcinoma

Purpose To evaluate parameters derived from 68 Ga-PSMA-11 PET/CT images for discriminating pathological characteristics in primary clear-cell renal cell carcinoma (ccRCC). Methods The study retrospectively examined data for 36 ccRCC patients with preoperative 68 Ga-PSMA-11 PET/CT scan and surgical s...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2021-02, Vol.48 (2), p.561-569
Main Authors: Gao, Jie, Xu, Qinfeng, Fu, Yao, He, Kuiqiang, Zhang, Chengwei, Zhang, Qing, Shi, Jiong, Zhao, Xiaozhi, Wang, Feng, Guo, Hongqian
Format: Article
Language:English
Subjects:
Cardiology
Clear cell-type renal cell carcinoma
Computed tomography
Confidence intervals
Evaluation
Imaging
Kidney cancer
Medical imaging
Medicine
Medicine & Public Health
Necrosis
Nuclear Medicine
Oncology
Oncology – Genitourinary
Original Article
Orthopedics
Parameter estimation
Pathology
Positron emission
Radiology
Sensitivity
Subgroups
Tomography
Tumors
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Summary:Purpose To evaluate parameters derived from 68 Ga-PSMA-11 PET/CT images for discriminating pathological characteristics in primary clear-cell renal cell carcinoma (ccRCC). Methods The study retrospectively examined data for 36 ccRCC patients with preoperative 68 Ga-PSMA-11 PET/CT scan and surgical specimens. Radiological parameters including maximal tumor diameter, mean CT value, and maximal standard uptake value (SUV max ) were derived from PET/CT images. Pathological characteristics included WHO/ISUP grade and adverse pathology (tumor necrosis or sarcomatoid or rhabdoid feature). Values of radiological parameters were compared within subgroups of pathological characteristics. Receiver operating characteristic (ROC) curve analysis was used for the effectiveness of radiological parameters in differentiating pathological characteristics, estimating area under the ROC curve (AUC) and 95% confidence intervals (CIs). Results The WHO/ISUP grade distribution for 36 tumors was grade 1, 9 (25.0%); grade 2, 12 (33.3%); grade 3, 9 (25.0%); and grade 4, 6 (16.7%). Adverse pathology was positive for 15 (41.7%). Radiological tumor diameter and SUVmax significantly differed by WHO/ISUP grade, pT stage, and adverse pathology (all P  
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-020-04916-6