The Role of Arachidonic Acid Metabolism in Myocardial Ischemia–Reperfusion Injury

Patients with myocardial ischemic diseases or who are undergoing one of various heart treatments, such as open heart surgery, coronary artery bypass grafting, percutaneous coronary artery intervention or drug thrombolysis, face myocardial ischemia–reperfusion injury (MIRI). However, no effective tre...

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Bibliographic Details
Published in:Cell biochemistry and biophysics 2020-09, Vol.78 (3), p.255-265
Main Authors: Zhang, Changjiang, He, Meiling, Ni, Lihua, He, Ke, Su, Ke, Deng, Yinzhi, Li, Yuanhong, Xia, Hao
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Arachidonic acid
Arachidonic Acid - metabolism
Autophagy
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biotechnology
Bypass
Calcium - metabolism
Cardiovascular disease
Cardiovascular diseases
Cell Biology
Coronary artery
Coronary vessels
Cytochrome P-450 CYP4A
Cytochrome P450
Cytochrome P450 monooxygenase
Cytochromes P450
Heart surgery
Humans
Immune System
Inflammation
Injuries
Ischemia
Life Sciences
Lipoxygenase
Liquid oxygen
Metabolic pathways
Metabolism
Metabolites
Mice
Myocardial ischemia
Myocardial Reperfusion Injury - pathology
Oxidative Stress
Pharmacology/Toxicology
Prognosis
Prostaglandin endoperoxide synthase
Reperfusion
Reperfusion Injury - pathology
Review Paper
Thrombolysis
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Summary:Patients with myocardial ischemic diseases or who are undergoing one of various heart treatments, such as open heart surgery, coronary artery bypass grafting, percutaneous coronary artery intervention or drug thrombolysis, face myocardial ischemia–reperfusion injury (MIRI). However, no effective treatment is currently available for MIRI. To improve the prognosis of people with cardiovascular disease, it is important to research the mechanism of MIRI. Arachidonic acid (AA) is one of the focuses of current research. The various metabolic pathways of AA are closely related to the development of cardiovascular disease, and the roles of various metabolites in ischemia–reperfusion injury have gradually been confirmed. AA is mainly metabolized in the cyclooxygenase (COX) pathway, lipoxygenase (LOX) pathway, and cytochrome P450 monooxygenase (CYP) pathway. This paper summarizes the progress of research on these three major AA metabolic pathways with respect to MIRI.
ISSN:1085-9195
1559-0283
DOI:10.1007/s12013-020-00928-z