Pharmacotranscriptomics of peptide drugs with neuroprotective properties

Here we present a review of studies on the effects of peptides with neuroprotective properties on gene transcription in nerve cells. The few published works in this area clearly demonstrate massive changes in cell transcriptomes induced by peptides under normal conditions and under conditions of exp...

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Bibliographic Details
Published in:Medicinal research reviews 2021-03, Vol.41 (2), p.754-769
Main Authors: Dergunova, Lyudmila V., Filippenkov, Ivan B., Limborska, Svetlana A., Myasoedov, Nikolai F.
Format: Article
Language:English
Subjects:
Brain
brain ischemia
circular RNA
Ischemia
microRNA
MicroRNAs
mRNA
noncoding RNA
peptide drugs
Peptides
pharmacotranscriptomics
regulatory peptides
Transcription factors
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Summary:Here we present a review of studies on the effects of peptides with neuroprotective properties on gene transcription in nerve cells. The few published works in this area clearly demonstrate massive changes in cell transcriptomes induced by peptides under normal conditions and under conditions of experimental brain ischemia. These changes significantly affect signaling and metabolic pathways, affecting various body systems and confirming the multiple target actions of peptides. The importance of noncoding RNAs in the regulation of these processes is shown, and we discuss the prospects of research for determining the main mechanisms of peptide regulation, which is necessary for the further development of drugs with targeted neuroprotective effects.
ISSN:0198-6325
1098-1128
DOI:10.1002/med.21704