Circulating high-sensitivity troponin T and microRNAs as markers of myocardial damage during childhood leukaemia treatment

Background We investigated whether plasma high-sensitivity cardiac troponin T (hs-cTnT) and circulating heart-associated microRNA (miRs) are increased in children with leukaemias during anthracycline-based chemotherapeutic treatment. Methods In vitro human pluripotent stem cell (hPSC)-derived cardio...

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Bibliographic Details
Published in:Pediatric research 2021-04, Vol.89 (5), p.1245-1252
Main Authors: Cheung, Yiu-fai, Li, Vivian Wing-yi, Lai, Clare Tik-man, Shin, Vivian Yvonne, Keung, Wendy, Cheuk, Daniel Ka-leung, Kwong, Ava, Li, Ronald Adolphus, Chan, Godfrey Chi-fung
Format: Article
Language:English
Subjects:
Adolescent
Anthracyclines - chemistry
Antineoplastic Agents - pharmacology
Chemotherapy
Child
Child, Preschool
Childhood
Clinical Research Article
Culture Media
Doxorubicin
Female
Heart - physiology
Humans
In Vitro Techniques
Infant
Leukemia
Male
Medicine
Medicine & Public Health
MicroRNAs
MicroRNAs - blood
Myocardium - pathology
Pediatric Surgery
Pediatrics
Plasma
Pluripotent Stem Cells - cytology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Troponin T - blood
Ventricular Dysfunction, Left - complications
Ventricular Dysfunction, Left - diagnosis
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Summary:Background We investigated whether plasma high-sensitivity cardiac troponin T (hs-cTnT) and circulating heart-associated microRNA (miRs) are increased in children with leukaemias during anthracycline-based chemotherapeutic treatment. Methods In vitro human pluripotent stem cell (hPSC)-derived cardiomyocyte model showed that miR-1, miR-133a, miR-208a, miR-208b, and miR-499 are released from cells into culture medium in a time- and dose-dependent manner on doxorubicin exposure. Left ventricular (LV) myocardial deformation and circulating heart-associated miRs and plasma hs-cTnT during and after completion of chemotherapy were determined in 40 children with newly diagnosed acute leukaemia. Results Significant reduction of LV global longitudinal strain and strain rates were found within 1 week after completion of anthracycline therapy in the induction phase of treatment (all p  
ISSN:0031-3998
1530-0447
DOI:10.1038/s41390-020-1049-5