A pilot study to evaluate urine LAM assay for diagnosis of pulmonary tuberculosis among non-HIV patients

There is a great need to improve diagnostic tools for tuberculosis where the majority are without HIV co-infection in resource-poor settings and high-burden areas such as India. The urine LAM assay has not hitherto been studied and may have a role to play. Our study found that, as a stand-alone diag...

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Bibliographic Details
Published in:Tropical doctor 2020-10, Vol.50 (4), p.343-346
Main Authors: Gupta, Akshita, Kumar, Ajay, Ashraf, Asem Ali, Madigubba, Haritha, Chawla, Kiran
Format: Article
Language:English
Subjects:
Adult
Aged
Bacteriological Techniques - methods
Female
Humans
India
Lipopolysaccharides - urine
Male
Middle Aged
Mycobacterium tuberculosis - immunology
Mycobacterium tuberculosis - isolation & purification
Pilot Projects
Sensitivity and Specificity
Sputum - microbiology
Tuberculosis, Pulmonary - diagnosis
Tuberculosis, Pulmonary - microbiology
Tuberculosis, Pulmonary - urine
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Summary:There is a great need to improve diagnostic tools for tuberculosis where the majority are without HIV co-infection in resource-poor settings and high-burden areas such as India. The urine LAM assay has not hitherto been studied and may have a role to play. Our study found that, as a stand-alone diagnostic tool, the assay was suboptimal when compared to Xpert MTB/Rif. However, a combination of LAM assay along with sputum microscopy may be useful in settings where molecular testing is unavailable.
ISSN:0049-4755
1758-1133
DOI:10.1177/0049475520936164