Risk factors and renal outcomes of low bone mineral density in patients with non-dialysis chronic kidney disease

• Published in: Osteoporosis international 2020-12, Vol.31 (12), p.2373-2382
• Main Authors: Hyun, Y. Y., Lee, K.-B., Han, S. H., Choi, K. H., Park, H. C., Oh, Y. K., Park, S. K., Oh, K.-H., Ahn, C.
• Format: Article
• Language: English
• Subjects: Absorptiometry, Photon; Adult; Aged; Bone Density; Bone Diseases, Metabolic - epidemiology; Bone Diseases, Metabolic - etiology; Bone mineral density; Dialysis; Dietary intake; Discordance; Dual energy X-ray absorptiometry; End-stage renal disease; Endocrinology; Epidermal growth factor receptors; Female; Hemodialysis; Humans; Kidney diseases; Male; Medicine; Medicine & Public Health; Middle Aged; Original Article; Orthopedics; Osteopenia; Osteoporosis; Physical activity; Renal Insufficiency, Chronic - complications; Rheumatology; Risk Factors; Spine (lumbar)
• ISSN: 0937-941X; 1433-2965
• DOI: 10.1007/s00198-020-05531-9

Summary Bone disorder is a common complication of chronic kidney disease (CKD). The clinical usefulness of bone mineral density (BMD) in CKD is not well known. Our study shows that low BMD is associated with physical activity and dietary Na/K intake ratio and can predict poor renal outcome in non-dialysis CKD. Purpose Despite evidence of a link between bone mineral disorders and chronic kidney disease (CKD), the clinical implications of bone mineral density (BMD) in CKD are not well established. We investigated risk factors and renal outcomes of low BMD in CKD. Methods We analyzed data from the KNOW-CKD. BMD measured by dual-energy x-ray absorptiometry was classified by T score: normal ( T score ≥ − 1.0), osteopenia (− 1.0 >  T score > − 2.5), and osteoporosis ( T score ≤ − 2.5) of the lumbar spine, hip, or femoral neck. Logistic regression analysis to assess risk factors of low BMD ( T score