Phytochemical investigation and anticholinesterase activity of ethyl acetate fraction of Myristica fragrans Houtt. seeds

In this work, -hexane, chloroform, and ethyl acetate fractions of the methanol extract of Houtt. seeds were evaluated against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) Ellman's method. It was found that all fractions depicted no anti-AChE activity, however, they were active t...

Full description

Saved in:
Bibliographic Details
Published in:Natural product research 2022-01, Vol.36 (2), p.610-616
Main Authors: Omidpanah, Sahar, Vahedi-Mazdabadi, Yasaman, Manayi, Azadeh, Rastegari, Arezoo, Hariri, Roshanak, Mortazavi-Ardestani, Elahe, Eftekhari, Mahdieh, Khanavi, Mahnaz, Akbarzadeh, Tahmineh, Saeedi, Mina
Format: Article
Language:English
Subjects:
Acetates
Acetylcholinesterase
Butyrylcholinesterase
Cholinesterase Inhibitors - pharmacology
Myristica
Phytochemicals - pharmacology
Plant Extracts - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this work, -hexane, chloroform, and ethyl acetate fractions of the methanol extract of Houtt. seeds were evaluated against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) Ellman's method. It was found that all fractions depicted no anti-AChE activity, however, they were active toward BChE with IC values of 361.8, 215.0, and 145.8 µg/mL, respectively comparing with donepezil as the reference drug (IC = 1.97 µg/mL). The ethyl acetate fraction which also showed high neuroprotectivity and metal chelating ability was selected for the phytochemical analysis. Our results confirmed the presence of trimyristin and 5,7-diacetyl chrysin (reported for the first time in ) in the corresponding fraction.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1788555