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Association of bullous pemphigoid and comorbid health conditions: a case–control study
Background Bullous pemphigoid is an autoimmune skin disease characterized by the formation of blisters between the epidermis and dermis. Comorbidities of pemphigoid have not been well-described. Identification of comorbidities associated with pemphigoid is important to decrease morbidity and mortali...
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Published in: | Archives of Dermatological Research 2021-07, Vol.313 (5), p.327-332 |
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description | Background
Bullous pemphigoid is an autoimmune skin disease characterized by the formation of blisters between the epidermis and dermis. Comorbidities of pemphigoid have not been well-described. Identification of comorbidities associated with pemphigoid is important to decrease morbidity and mortality.
Objective
To identify the comorbid health conditions of bullous pemphigoid.
Methods
This was a case–control study of 91 cases of pemphigoid verified by clinical and laboratory diagnosis and 546 age- and sex-matched controls with complete follow-up at a large metropolitan quaternary care medical center.
Results
The average age of bullous pemphigoid patients was 76 years and 53% of patients were female. Forty-eight (53%) of the BP patients had a history of inpatient hospitalization, of which 22 (24.2%) were hospitalized for either previously undiagnosed BP or an exacerbation of BP. Bullous pemphigoid was significantly associated with hypertension [adjusted odds ratio (95% confidence interval)]: [2.03 (1.24–3.32)], diabetes mellitus [2.59 (1.60–4.19)], chronic kidney disease [2.29 (1.19–4.40)], end-stage renal disease [3.82 (1.48–9.85)], basal cell carcinoma of the skin [6.00 (1.94–18.6)], and obstructive sleep apnea [5.23 (2.45–11.19)]. 78% of BP patients used at least one systemic immunosuppressant. There was no significant association between treatments for pemphigoid and any of the comorbidities.
Conclusions
Bullous pemphigoid patients need screening for comorbid health conditions even though treatment options do not seem to be associated with these comorbidities. |
doi_str_mv | 10.1007/s00403-020-02100-2 |
format | article |
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Bullous pemphigoid is an autoimmune skin disease characterized by the formation of blisters between the epidermis and dermis. Comorbidities of pemphigoid have not been well-described. Identification of comorbidities associated with pemphigoid is important to decrease morbidity and mortality.
Objective
To identify the comorbid health conditions of bullous pemphigoid.
Methods
This was a case–control study of 91 cases of pemphigoid verified by clinical and laboratory diagnosis and 546 age- and sex-matched controls with complete follow-up at a large metropolitan quaternary care medical center.
Results
The average age of bullous pemphigoid patients was 76 years and 53% of patients were female. Forty-eight (53%) of the BP patients had a history of inpatient hospitalization, of which 22 (24.2%) were hospitalized for either previously undiagnosed BP or an exacerbation of BP. Bullous pemphigoid was significantly associated with hypertension [adjusted odds ratio (95% confidence interval)]: [2.03 (1.24–3.32)], diabetes mellitus [2.59 (1.60–4.19)], chronic kidney disease [2.29 (1.19–4.40)], end-stage renal disease [3.82 (1.48–9.85)], basal cell carcinoma of the skin [6.00 (1.94–18.6)], and obstructive sleep apnea [5.23 (2.45–11.19)]. 78% of BP patients used at least one systemic immunosuppressant. There was no significant association between treatments for pemphigoid and any of the comorbidities.
Conclusions
Bullous pemphigoid patients need screening for comorbid health conditions even though treatment options do not seem to be associated with these comorbidities.</description><identifier>ISSN: 0340-3696</identifier><identifier>EISSN: 1432-069X</identifier><identifier>DOI: 10.1007/s00403-020-02100-2</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Apnea ; Autoimmune diseases ; Basal cell carcinoma ; Bullous pemphigoid ; Comorbidity ; Dermatology ; Dermis ; Diabetes mellitus ; End-stage renal disease ; Epidemiology ; Epidermis ; Hypertension ; Kidney diseases ; Medicine ; Medicine & Public Health ; Morbidity ; Original Paper ; Patients ; Skin diseases ; Sleep apnea ; Sleep disorders</subject><ispartof>Archives of Dermatological Research, 2021-07, Vol.313 (5), p.327-332</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-3f47512d38ec1c923d64f35f85daf0be2b5e6e27660554d11884f4c5635866b03</citedby><cites>FETCH-LOGICAL-c352t-3f47512d38ec1c923d64f35f85daf0be2b5e6e27660554d11884f4c5635866b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Lee, Sherry</creatorcontrib><creatorcontrib>Rastogi, Supriya</creatorcontrib><creatorcontrib>Hsu, Derek Y.</creatorcontrib><creatorcontrib>Nardone, Beatrice</creatorcontrib><creatorcontrib>Silverberg, Jonathan I.</creatorcontrib><title>Association of bullous pemphigoid and comorbid health conditions: a case–control study</title><title>Archives of Dermatological Research</title><addtitle>Arch Dermatol Res</addtitle><description>Background
Bullous pemphigoid is an autoimmune skin disease characterized by the formation of blisters between the epidermis and dermis. Comorbidities of pemphigoid have not been well-described. Identification of comorbidities associated with pemphigoid is important to decrease morbidity and mortality.
Objective
To identify the comorbid health conditions of bullous pemphigoid.
Methods
This was a case–control study of 91 cases of pemphigoid verified by clinical and laboratory diagnosis and 546 age- and sex-matched controls with complete follow-up at a large metropolitan quaternary care medical center.
Results
The average age of bullous pemphigoid patients was 76 years and 53% of patients were female. Forty-eight (53%) of the BP patients had a history of inpatient hospitalization, of which 22 (24.2%) were hospitalized for either previously undiagnosed BP or an exacerbation of BP. Bullous pemphigoid was significantly associated with hypertension [adjusted odds ratio (95% confidence interval)]: [2.03 (1.24–3.32)], diabetes mellitus [2.59 (1.60–4.19)], chronic kidney disease [2.29 (1.19–4.40)], end-stage renal disease [3.82 (1.48–9.85)], basal cell carcinoma of the skin [6.00 (1.94–18.6)], and obstructive sleep apnea [5.23 (2.45–11.19)]. 78% of BP patients used at least one systemic immunosuppressant. There was no significant association between treatments for pemphigoid and any of the comorbidities.
Conclusions
Bullous pemphigoid patients need screening for comorbid health conditions even though treatment options do not seem to be associated with these comorbidities.</description><subject>Apnea</subject><subject>Autoimmune diseases</subject><subject>Basal cell carcinoma</subject><subject>Bullous pemphigoid</subject><subject>Comorbidity</subject><subject>Dermatology</subject><subject>Dermis</subject><subject>Diabetes mellitus</subject><subject>End-stage renal disease</subject><subject>Epidemiology</subject><subject>Epidermis</subject><subject>Hypertension</subject><subject>Kidney diseases</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Morbidity</subject><subject>Original Paper</subject><subject>Patients</subject><subject>Skin diseases</subject><subject>Sleep apnea</subject><subject>Sleep disorders</subject><issn>0340-3696</issn><issn>1432-069X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9UMtKxEAQHETBZd0f8BTw4iXamVcSb8viCwQvCnsbJvPYzZJk4kxy2Jv_4B_6Jc4aQfBgQ9NUU1V0F0LnGVxlAPl1AKBAUsAQO25SfIRmGSU4BV6uj9EMCIWU8JKfokUIO4iVA8WQz9B6GYJTtRxq1yXOJtXYNG4MSW_afltvXK0T2elEudb5KoKtkc2wjbjT9UETbhKZKBnM5_tHXA7eNUkYRr0_QydWNsEsfuYcvd7dvqwe0qfn-8fV8ilVhOEhJZbmLMOaFEZlqsREc2oJswXT0kJlcMUMNzjnHBijOsuKglqqGCes4LwCMkeXk2_v3dtowiDaOijTNLIz8RGBKSbAeJ7zSL34Q9250XfxOoEZyXFJORwM8cRS3oXgjRW9r1vp9yIDcchbTHmLmLf4zlvgKCKTKERytzH-1_of1RexcoKn</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Lee, Sherry</creator><creator>Rastogi, Supriya</creator><creator>Hsu, Derek Y.</creator><creator>Nardone, Beatrice</creator><creator>Silverberg, Jonathan I.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20210701</creationdate><title>Association of bullous pemphigoid and comorbid health conditions: a case–control study</title><author>Lee, Sherry ; Rastogi, Supriya ; Hsu, Derek Y. ; Nardone, Beatrice ; Silverberg, Jonathan I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-3f47512d38ec1c923d64f35f85daf0be2b5e6e27660554d11884f4c5635866b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Apnea</topic><topic>Autoimmune diseases</topic><topic>Basal cell carcinoma</topic><topic>Bullous pemphigoid</topic><topic>Comorbidity</topic><topic>Dermatology</topic><topic>Dermis</topic><topic>Diabetes mellitus</topic><topic>End-stage renal disease</topic><topic>Epidemiology</topic><topic>Epidermis</topic><topic>Hypertension</topic><topic>Kidney diseases</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Morbidity</topic><topic>Original Paper</topic><topic>Patients</topic><topic>Skin diseases</topic><topic>Sleep apnea</topic><topic>Sleep disorders</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Sherry</creatorcontrib><creatorcontrib>Rastogi, Supriya</creatorcontrib><creatorcontrib>Hsu, Derek Y.</creatorcontrib><creatorcontrib>Nardone, Beatrice</creatorcontrib><creatorcontrib>Silverberg, Jonathan I.</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of Dermatological Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Sherry</au><au>Rastogi, Supriya</au><au>Hsu, Derek Y.</au><au>Nardone, Beatrice</au><au>Silverberg, Jonathan I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of bullous pemphigoid and comorbid health conditions: a case–control study</atitle><jtitle>Archives of Dermatological Research</jtitle><stitle>Arch Dermatol Res</stitle><date>2021-07-01</date><risdate>2021</risdate><volume>313</volume><issue>5</issue><spage>327</spage><epage>332</epage><pages>327-332</pages><issn>0340-3696</issn><eissn>1432-069X</eissn><abstract>Background
Bullous pemphigoid is an autoimmune skin disease characterized by the formation of blisters between the epidermis and dermis. Comorbidities of pemphigoid have not been well-described. Identification of comorbidities associated with pemphigoid is important to decrease morbidity and mortality.
Objective
To identify the comorbid health conditions of bullous pemphigoid.
Methods
This was a case–control study of 91 cases of pemphigoid verified by clinical and laboratory diagnosis and 546 age- and sex-matched controls with complete follow-up at a large metropolitan quaternary care medical center.
Results
The average age of bullous pemphigoid patients was 76 years and 53% of patients were female. Forty-eight (53%) of the BP patients had a history of inpatient hospitalization, of which 22 (24.2%) were hospitalized for either previously undiagnosed BP or an exacerbation of BP. Bullous pemphigoid was significantly associated with hypertension [adjusted odds ratio (95% confidence interval)]: [2.03 (1.24–3.32)], diabetes mellitus [2.59 (1.60–4.19)], chronic kidney disease [2.29 (1.19–4.40)], end-stage renal disease [3.82 (1.48–9.85)], basal cell carcinoma of the skin [6.00 (1.94–18.6)], and obstructive sleep apnea [5.23 (2.45–11.19)]. 78% of BP patients used at least one systemic immunosuppressant. There was no significant association between treatments for pemphigoid and any of the comorbidities.
Conclusions
Bullous pemphigoid patients need screening for comorbid health conditions even though treatment options do not seem to be associated with these comorbidities.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00403-020-02100-2</doi><tpages>6</tpages></addata></record> |
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subjects | Apnea Autoimmune diseases Basal cell carcinoma Bullous pemphigoid Comorbidity Dermatology Dermis Diabetes mellitus End-stage renal disease Epidemiology Epidermis Hypertension Kidney diseases Medicine Medicine & Public Health Morbidity Original Paper Patients Skin diseases Sleep apnea Sleep disorders |
title | Association of bullous pemphigoid and comorbid health conditions: a case–control study |
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