Factors Associated With Aggressiveness of End-of-Life Care for Lung Cancer Patients and Associated Costs of Care

• Published in: Clinical lung cancer 2021-05, Vol.22 (3), p.e320-e328
• Main Authors: Bylicki, Olivier, Rivière, Fréderic, Tournier, Charlène, Canoui-Poitrine, Florence, Grassin, Fréderic, Margery, Jacques, Prodel, Martin, Vainchtock, Alexandre, Assié, Jean-Baptiste, Chouaïd, Christos
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aggressiveness; Databases, Factual; End of life; Female; France; Health care costs; Health Care Costs - statistics & numerical data; Hospitalization - economics; Hospitalization - statistics & numerical data; Humans; Intensive Care Units - economics; Intensive Care Units - statistics & numerical data; Lung cancer; Lung Neoplasms - economics; Lung Neoplasms - therapy; Male; Middle Aged; Palliative care; Palliative Care - economics; Palliative Care - statistics & numerical data; Retrospective Studies; Sex Factors; Terminal Care - economics; Terminal Care - methods; Young Adult
• ISSN: 1525-7304; 1938-0690
• DOI: 10.1016/j.cllc.2020.05.017

Results of previous studies demonstrated that high-intensity end-of-life (EOL) care improves neither cancer patients’ survival nor quality of life. Our objective was to assess the incidence of and factors associated with aggressiveness of care during the last 30 days of life (DOL) of lung cancer (LC) patients and the impacts of aggressiveness of care in EOL-care costs. Using French national hospital database, all patients with LC who died between January 1, 2010, and December 31, 2011, or between January 1, 2015, and January 31, 2016, were included. EOL-care aggressiveness was assessed using the following criteria: chemotherapy administered within the last 14 DOL; more than one hospitalization within the last 30 DOL; admission to the intensive care unit within the last 30 DOL; and palliative care initiated < 3 days before death. Expenditures were limited to direct costs, from a health care payer’s perspective. Among 79,746 adult LC patients identified; 57% had at least one indicator of EOL-care aggressiveness (49% repeated hospitalizations, 12% intensive care unit admissions, 9% chemotherapy, 5% palliative care). It increased significantly between the 2 periods (56% vs. 58%, P < .001). Young age, male sex, shorter time since diagnosis, comorbidities, no malnutrition, type of care facility other than general hospital, social deprivation, and low-density population were independently associated with having one or more indicator of aggressive EOL care. The mean EOL cost was €8152 ± 5117 per patient, but the cost was significantly higher for patients with at least one EOL-care aggressiveness criterion (€9480 vs. €6376, P < .001). In France, a majority of LC patients had at least one criterion of aggressive EOL care that had a major economic impact on the health care system. High-intensity end-of-life (EOL) care improves neither cancer patients’ survival nor quality of life. We assessed the incidence of and factors associated with aggressiveness of care of lung cancer patients and the impacts of aggressiveness of care in EOL-care costs. Despite the growing attention to providing appropriate EOL care, 57% of the deceased LC patients had at least one EOL-care aggressiveness indicator.