Novel ursane-type triterpene from the fresh leaves of Carissa carandas and evaluation of cytotoxicity

One novel ursolic acid derivative sabiracin 1 (11,25-epoxy-3β-hydroxy-urs-12-en-28-oic acid) was isolated from the leaves of Carissa carandas, together with five known compounds para hydroxy benzaldehyde (2), ursolic acid (3), carissin (4), 22α-hydroxyursolic acid (5) and β-sitosterol-3-O-β-D-glucop...

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Bibliographic Details
Published in:Journal of asian natural products research 2021-09, Vol.23 (9), p.892-898
Main Authors: Bano, Zarina, Begum, Sabira, Ali, Syed Saqib, Kiran, Zareena, Siddiqui, Bina S., Khawaja, Shariqa, Ahmed, Ayaz
Format: Article
Language:English
Subjects:
11,25-epoxyursolic acid
Acids
Apocynaceae
Benzaldehyde
Carissa carandas
Cytotoxicity
Lung cancer
novel ursolic acid derivative
Oral cancer
Toxicity
Tumor cell lines
Ursolic acid
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Summary:One novel ursolic acid derivative sabiracin 1 (11,25-epoxy-3β-hydroxy-urs-12-en-28-oic acid) was isolated from the leaves of Carissa carandas, together with five known compounds para hydroxy benzaldehyde (2), ursolic acid (3), carissin (4), 22α-hydroxyursolic acid (5) and β-sitosterol-3-O-β-D-glucopyranoside (6). Compounds 2 and 5 were isolated for the first time from this genus. Structure elucidation was done by the help of spectroscopic techniques. Compounds 1-3, 5 and 6 were examined against oral cancer (CAL-27) and lung cancer (NCI-H460) cell lines. 6 showed good activity against oral cancer (IC 50 18.69 µM), moderate activity against lung cancer (IC 50 63.34 µM) and no cytotoxicity against normal cell lines.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2020.1791098