Recurrent Talaromyces marneffei Infection Presenting with Intestinal Obstruction in a Patient with Systemic Lupus Erythematosus

Talaromyces marneffei is an important opportunistic pathogen mainly afflicting the HIV-infected patients, in rare instance, it could cause infection in non-HIV-infected individuals. We report a 51-year-old Chinese woman who, with histories of SLE for 14 years and disseminated talaromycosis for 4 yea...

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Bibliographic Details
Published in:Mycopathologia (1975) 2020-08, Vol.185 (4), p.717-726
Main Authors: Zhao, Yu-Kun, Liu, Jing-Ye, Liu, Juan-Hua, Lu, Sha, Wu, Hui-Hui, Luo, Di-Qing
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Case Report
Diseases
Eukaryotic Microbiology
Health aspects
HIV
Human immunodeficiency virus
Infections
Intestinal obstruction
Intestine
Intestines
Itraconazole
Life Sciences
Lupus
Medical Microbiology
Microbial Ecology
Microbiology
Obstructions
Opportunist infection
Paraffin
Plant Sciences
Recurrent infection
Relapse
Systemic lupus erythematosus
Talaromyces
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Summary:Talaromyces marneffei is an important opportunistic pathogen mainly afflicting the HIV-infected patients, in rare instance, it could cause infection in non-HIV-infected individuals. We report a 51-year-old Chinese woman who, with histories of SLE for 14 years and disseminated talaromycosis for 4 years, occurred partial intestinal obstruction that was demonstrated to be caused by Talaromyces marneffei infection. The randomly amplified polymorphic DNA results of paraffin-embedded tissues from both the present episode and the previous infection suggested that the present infection was a recurrent. The patient was performed excision of involved intestine and treated with oral itraconazole at a daily dose of 400 mg for 3 months, leading to an excellent response. However, she died with unknown reason more than a year later. We also reviewed the literature on Talaromyces marneffei infection associated with SLE as well as intestinal talaromycosis alone.
ISSN:0301-486X
1573-0832
DOI:10.1007/s11046-020-00469-2