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Rotavirus outbreak among adults in a university hospital in Germany
•A rotavirus outbreak among adults was detected in a university hospital in Germany.•Rapid typing identified rotavirus G2P[4] as the etiologic agent.•Infection control measures successfully contained the outbreak.•Phylogenetic analysis allowed to identify outbreak associated cases. Rotaviruses are t...
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Published in: | Journal of clinical virology 2020-08, Vol.129, p.104532-104532, Article 104532 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | •A rotavirus outbreak among adults was detected in a university hospital in Germany.•Rapid typing identified rotavirus G2P[4] as the etiologic agent.•Infection control measures successfully contained the outbreak.•Phylogenetic analysis allowed to identify outbreak associated cases.
Rotaviruses are the main cause of acute viral gastroenteritis in children under five years of age. Adults seem to be less frequently affected by rotaviruses most likely due to partial immunity resulting from prior infections.
To describe a hospital-associated outbreak of rotavirus infections among adults. Study design: Routine diagnostics and contact screening of symptomatic patients hospitalized at the university hospital of Freiburg. For rotavirus-positive patients, we performed rotavirus genotyping of all rotavirus RT-PCR positive samples and phylogenetic analysis.
Between December 2016 and April 2017 routine diagnostics showed an unexpectedly high number of rotavirus infections among adults with the exception of one pediatric case. In total, 32 temporal-associated cases were identified. Among these, two asymptomatic cases were detected. Genotyping showed that all isolates belonged to rotavirus G2P[4]. Phylogenetic analysis confirmed an outbreak. Infection prevention and control successfully contained further spread.
Infections with rotavirus are rare among adults but may spread between patients making timely recognition of rotavirus infections important for infection control. Rapid phylogenetic analysis is crucial for proactive infection control. |
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ISSN: | 1386-6532 1873-5967 |
DOI: | 10.1016/j.jcv.2020.104532 |