The prognostic value of pain in castration-sensitive prostate cancer

Background Cancer-related pain, usually associated with bone metastases, is a frequent and debilitating morbidity in patients with prostate cancer. To date there are only limited data regarding the prognostic role of pain in men with metastatic castration-sensitive prostate cancer (mCSPC). The objec...

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Bibliographic Details
Published in:Prostate cancer and prostatic diseases 2020-12, Vol.23 (4), p.654-660
Main Authors: Iacovelli, Roberto, Ciccarese, Chiara, Caffo, Orazio, De Giorgi, Ugo, Tucci, Marcello, Mosillo, Claudia, Bimbatti, Davide, Pierantoni, Francesco, Maines, Francesca, Casadei, Chiara, Buttigliero, Consuelo, Milella, Michele, Tortora, Giampaolo
Format: Article
Language:English
Subjects:
631/67/1059
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Analgesics
Antigens
Biomedical and Life Sciences
Biomedicine
Cancer patients
Cancer Research
Castration
Health hazards
Lymph nodes
Medical prognosis
Metastases
Metastasis
Morbidity
Oncology
Pain
Prognosis
Prostate cancer
Prostate-specific antigen
Rank tests
Statistical models
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Summary:Background Cancer-related pain, usually associated with bone metastases, is a frequent and debilitating morbidity in patients with prostate cancer. To date there are only limited data regarding the prognostic role of pain in men with metastatic castration-sensitive prostate cancer (mCSPC). The objective of our analysis was to assess if the presence of pain can be considered an independent prognostic factor in mCSPC patients. Methods A retrospective analysis was performed on patients with mCSPC referring to six oncology centers in Italy. Clinical and pathological features were recorded. Patients were considered to have pain if this was reported within the patient’s file or in case of a chronic analgesic therapy was found among the concomitant medications. Survivals were estimated by the Kaplan–Meier method, and compared across groups using the log-rank test. Cox proportional hazard models, stratified according to the baseline characteristics, were used to estimate hazard ratios for overall survival (OS). All the variables were significant if p  
ISSN:1365-7852
1476-5608
DOI:10.1038/s41391-020-0255-x