Mortality and risk factor analysis for Candida blood stream infection: A three-year retrospective study

• Published in: Journal de mycologie médicale 2020-09, Vol.30 (3), p.101008-101008, Article 101008
• Main Authors: Muderris, T., Kaya, S., Ormen, B., Aksoy Gokmen, A., Varer Akpinar, C., Yurtsever Gul, S.
• Format: Article
• Language: English
• Subjects: Candida; Candidemia; Mortality; Predisposing conditions; Underlying conditions
• ISSN: 1156-5233; 1773-0449
• DOI: 10.1016/j.mycmed.2020.101008

•Candida parapsilosis was the most frequent causative agent in patients with candidemia.•Dialysis and concurrent bacteremia are strong predictors of mortality within 30 days in patients with candidemia.•Follow-up blood cultures have a protective role with lower mortality rates within 30 days in patients with candidemia. The aim of this study was to evaluate the possible risk factors for mortality in adult patients with candidemia by investigating the causative agents, underlying conditions and predisposing factors. The data including causative Candida species, predisposing factors, and underlying conditions of candidemia patients between the years 2015–2017 were collected and the impact of these factors on mortality was evaluated. Patients were divided into two groups as died (died patients within 30 days of the onset of candidemia) and survived and risk factors were evaluated for each group. We found 163 adult candidemia cases during the study period. Overall 30-day mortality was 40.5%. Candida parapsilosis was the most frequent causative agent (49.1%). C. parapsilosis candidemia was more common in the survived group compared with the died group (n: 49 (61.3%) vs. n: 31 (38.8%), P=0.888). Mortality rates were significantly higher in patients with dialysis (n: 27 (69.2%) vs. n: 12 (30.8%), P