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Obesity and load‐induced posttraumatic osteoarthritis in the absence of fracture or surgical trauma

Osteoarthritis is increasingly viewed as a heterogeneous disease with multiple phenotypic subgroups. Obesity enhances joint degeneration in mouse models of posttraumatic osteoarthritis (PTOA). Most models of PTOA involve damage to surrounding tissues caused by surgery/fracture; it is unclear if obes...

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Published in:Journal of orthopaedic research 2021-05, Vol.39 (5), p.1007-1016
Main Authors: Luna, Marysol, Guss, Jason D., Vasquez‐Bolanos, Laura S., Alepuz, Adrian J., Dornevil, Sophie, Strong, Jasmin, Alabi, Denise, Shi, Qiaojuan, Pannellini, Tania, Otero, Miguel, Brito, Ilana L., Meulen, Marjolein C. H., Goldring, Steven R., Hernandez, Christopher J.
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Language:English
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Summary:Osteoarthritis is increasingly viewed as a heterogeneous disease with multiple phenotypic subgroups. Obesity enhances joint degeneration in mouse models of posttraumatic osteoarthritis (PTOA). Most models of PTOA involve damage to surrounding tissues caused by surgery/fracture; it is unclear if obesity enhances cartilage degeneration in the absence of surgery/fracture. We used a nonsurgical animal model of load‐induced PTOA to determine the effect of obesity on cartilage degeneration 2 weeks after loading. Cartilage degeneration was caused by a single bout of cyclic tibial loading at either a high or moderate load magnitude in adult male mice with severe obesity (C57Bl6/J + high‐fat diet), mild obesity (toll‐like receptor 5 deficient mouse [TLR5KO]), or normal adiposity (C57Bl6/J mice + normal diet and TLR5KO mice in which obesity was prevented by manipulation of the gut microbiome). Two weeks after loading, cartilage degeneration occurred in limbs loaded at a high magnitude, as determined by OARSI scores (P 
ISSN:0736-0266
1554-527X
DOI:10.1002/jor.24799