Antibody kinetics in primary- and secondary-care physicians with mild to moderate SARS-CoV-2 infection

Three hundred and ninety-seven primary- and secondary-care physicians were tested for the presence of IgG (and IgA) antibodies against SARS-coronavirus-2 with a commercially available ELISA. In 19 of 20 individuals with PCR-proven infection and only mild to moderate symptoms not requiring hospitaliz...

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Bibliographic Details
Published in:Emerging microbes & infections 2020-01, Vol.9 (1), p.1692-1694
Main Authors: Orth-Höller, Dorothea, Eigentler, Angelika, Weseslindtner, Lukas, Möst, Johannes
Format: Article
Language:English
Subjects:
Antibodies, Viral - blood
antibody kinetics
Betacoronavirus - immunology
Coronavirus Infections - immunology
COVID-19
Female
Humans
IgG
Immunoglobulin A - blood
Immunoglobulin G - blood
Infections
Letter
Male
Middle Aged
Pandemics
Physicians, Primary Care
Pneumonia, Viral - immunology
primary- and secondary-care physicians
SARS-CoV-2
Secondary Care
serological testing
Severe acute respiratory syndrome coronavirus 2
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Summary:Three hundred and ninety-seven primary- and secondary-care physicians were tested for the presence of IgG (and IgA) antibodies against SARS-coronavirus-2 with a commercially available ELISA. In 19 of 20 individuals with PCR-proven infection and only mild to moderate symptoms not requiring hospitalization positive IgG levels occurred within two to three weeks. Among the remaining 377 persons without clear-cut evidence of infection, unequivocally positive IgG antibodies were found in only one, showing a surprisingly low prevalence (0.3%, 95% CI: 0.01-1.5) in physicians with likely contacts with infected patients in a region highly affected by the pandemic (Tyrol, Austria).
ISSN:2222-1751
2222-1751
DOI:10.1080/22221751.2020.1793690