Circulating markers of oxidative stress are associated with a muscle injury in patients with muscular dystrophy Duchenne

A small number of studies have confirmed the presence of oxidative damage in patients with Duchenne muscular dystrophy (DMD). Nevertheless, it is unknown if there a relationship of circulating markers of oxidative stress with a muscle injury. We evaluated if oxidative damage and anti-oxidant markers...

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Bibliographic Details
Published in:Brain & development (Tokyo. 1979) 2021-01, Vol.43 (1), p.111-120
Main Authors: Almeida-Becerril, Tomas, Rodríguez-Cruz, Maricela, Raúl Sánchez-González, Juan, Antonio Villaldama-Soriano, Marco, Atilano-Miguel, Salvador, Villa-Morales, Judith, Cárdenas-Conejo, Alan, Cárdenas-Vázquez, René
Format: Article
Language:English
Subjects:
Circulating markers
Duchenne muscular dystrophy
Muscle function
Oxidative damage
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Summary:A small number of studies have confirmed the presence of oxidative damage in patients with Duchenne muscular dystrophy (DMD). Nevertheless, it is unknown if there a relationship of circulating markers of oxidative stress with a muscle injury. We evaluated if oxidative damage and anti-oxidant markers are associated with muscle damage in DMD. This cross-sectional study included 24 patients with DMD classified in ambulatory and non-ambulatory. Markers of muscle damage (creatine kinase [CK]), oxidative damage (malondialdehyde [MDA], and 8-isoprostane), anti-oxidant function (Thiol and mRNA of NRF2 and NF-κB) and nitric oxide (NO) were quantified in circulation. Total NO, MDA, and 8-isoprostane concentrations were significantly (p 
ISSN:0387-7604
1872-7131
DOI:10.1016/j.braindev.2020.06.013