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Prefrontal dopaminergic system and its role in working memory and cognition in spinal cord‐injured rats
New Findings What is the central question of this study? How does spinal cord injury affect prefrontal cortex function and the expression of dopamine receptors? What is the main finding and its importance? Spinal cord injury impaired cognitive function, which was associated with reduced dopamine rec...
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| Published in: | Experimental physiology 2020-09, Vol.105 (9), p.1579-1587 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 1587 |
| container_issue | 9 |
| container_start_page | 1579 |
| container_title | Experimental physiology |
| container_volume | 105 |
| creator | Kheyrkhah, Hasan Soltani Zangbar, Hamid Salimi, Omid Shahabi, Parviz Alaei, HojjatAllah |
| description | New Findings
What is the central question of this study?
How does spinal cord injury affect prefrontal cortex function and the expression of dopamine receptors?
What is the main finding and its importance?
Spinal cord injury impaired cognitive function, which was associated with reduced dopamine receptor expression in the prefrontal cortex.
The effect of spinal cord injury (SCI) has been studied widely in paraplegia and motor areas of the brain, but its mechanisms in memory and cognitive impairment remain controversial. Here, we focused on the impact of SCI on prefrontal performance via dopamine levels and receptors. We divided 18 male rats into three groups, i.e. control, laminectomy and SCI groups. Laminectomy and SCI were induced at T10 of the spinal cord. One week later, after locomotor recovery, the novel object recognition and T‐maze (spontaneous alternation) tests were applied. After behavioural assessments, the rats were killed and their brain tissues harvested. According to the behavioural findings, cognitive function was impaired in the SCI group (P |
| doi_str_mv | 10.1113/EP088537 |
| format | article |
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What is the central question of this study?
How does spinal cord injury affect prefrontal cortex function and the expression of dopamine receptors?
What is the main finding and its importance?
Spinal cord injury impaired cognitive function, which was associated with reduced dopamine receptor expression in the prefrontal cortex.
The effect of spinal cord injury (SCI) has been studied widely in paraplegia and motor areas of the brain, but its mechanisms in memory and cognitive impairment remain controversial. Here, we focused on the impact of SCI on prefrontal performance via dopamine levels and receptors. We divided 18 male rats into three groups, i.e. control, laminectomy and SCI groups. Laminectomy and SCI were induced at T10 of the spinal cord. One week later, after locomotor recovery, the novel object recognition and T‐maze (spontaneous alternation) tests were applied. After behavioural assessments, the rats were killed and their brain tissues harvested. According to the behavioural findings, cognitive function was impaired in the SCI group (P < 0.05). Also, SCI significantly increased the dopamine level and decreased the expression of dopamine receptors in the prefrontal cortex 2 weeks after injury (P < 0.05). Given the role of dopamine in cognition, SCI could impair novel object recognition and spatial working memory via dopaminergic systems.</description><identifier>ISSN: 0958-0670</identifier><identifier>EISSN: 1469-445X</identifier><identifier>DOI: 10.1113/EP088537</identifier><identifier>PMID: 32654245</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>cognition ; Cognition & reasoning ; Cognitive ability ; Dopamine ; Dopamine receptors ; Memory ; Paraplegia ; Pattern recognition ; Prefrontal cortex ; Short term memory ; Spatial memory ; spatial working memory ; Spinal cord ; Spinal cord injuries ; spinal cord injury ; Spontaneous alternation</subject><ispartof>Experimental physiology, 2020-09, Vol.105 (9), p.1579-1587</ispartof><rights>2020 The Authors. Experimental Physiology © 2020 The Physiological Society</rights><rights>2020 The Authors. Experimental Physiology © 2020 The Physiological Society.</rights><rights>2020 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3849-231c9761b3cafd5dd90fde98f9668e32a753a7195c42ed58c319b4f82c125ee73</citedby><cites>FETCH-LOGICAL-c3849-231c9761b3cafd5dd90fde98f9668e32a753a7195c42ed58c319b4f82c125ee73</cites><orcidid>0000-0001-5594-5544</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1113%2FEP088537$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1113%2FEP088537$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,11541,27901,27902,46027,46451</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1113%2FEP088537$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32654245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kheyrkhah, Hasan</creatorcontrib><creatorcontrib>Soltani Zangbar, Hamid</creatorcontrib><creatorcontrib>Salimi, Omid</creatorcontrib><creatorcontrib>Shahabi, Parviz</creatorcontrib><creatorcontrib>Alaei, HojjatAllah</creatorcontrib><title>Prefrontal dopaminergic system and its role in working memory and cognition in spinal cord‐injured rats</title><title>Experimental physiology</title><addtitle>Exp Physiol</addtitle><description>New Findings
What is the central question of this study?
How does spinal cord injury affect prefrontal cortex function and the expression of dopamine receptors?
What is the main finding and its importance?
Spinal cord injury impaired cognitive function, which was associated with reduced dopamine receptor expression in the prefrontal cortex.
The effect of spinal cord injury (SCI) has been studied widely in paraplegia and motor areas of the brain, but its mechanisms in memory and cognitive impairment remain controversial. Here, we focused on the impact of SCI on prefrontal performance via dopamine levels and receptors. We divided 18 male rats into three groups, i.e. control, laminectomy and SCI groups. Laminectomy and SCI were induced at T10 of the spinal cord. One week later, after locomotor recovery, the novel object recognition and T‐maze (spontaneous alternation) tests were applied. After behavioural assessments, the rats were killed and their brain tissues harvested. According to the behavioural findings, cognitive function was impaired in the SCI group (P < 0.05). Also, SCI significantly increased the dopamine level and decreased the expression of dopamine receptors in the prefrontal cortex 2 weeks after injury (P < 0.05). Given the role of dopamine in cognition, SCI could impair novel object recognition and spatial working memory via dopaminergic systems.</description><subject>cognition</subject><subject>Cognition & reasoning</subject><subject>Cognitive ability</subject><subject>Dopamine</subject><subject>Dopamine receptors</subject><subject>Memory</subject><subject>Paraplegia</subject><subject>Pattern recognition</subject><subject>Prefrontal cortex</subject><subject>Short term memory</subject><subject>Spatial memory</subject><subject>spatial working memory</subject><subject>Spinal cord</subject><subject>Spinal cord injuries</subject><subject>spinal cord injury</subject><subject>Spontaneous alternation</subject><issn>0958-0670</issn><issn>1469-445X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kM1qGzEQgEVoqR2nkCcIgl562VS_u9IxhLQpBOpDArktsjRr5O5KjrSL8S2P0Gfsk3Qd2w0EcpqB-fgYPoTOKbmklPJvN3OilOTVCZpSUepCCPn4AU2JlqogZUUm6DTnFSGUEyU-oQlnpRRMyCny8wRNiqE3LXZxbTofIC29xXmbe-iwCQ77PuMUW8A-4E1Mv31Y4g66mLYvZxuXwfc-ht09r30YVTYm9_f5jw-rIYHDyfT5DH1sTJvh82HO0MP3m_vr2-Lu14-f11d3heVK6IJxanVV0gW3pnHSOU0aB1o1uiwVcGYqyU1FtbSCgZPKcqoXolHMUiYBKj5DX_fedYpPA-S-7ny20LYmQBxyzQTjkiol5Ih-eYOu4pDG_3cUV4pJSsir0KaY85irXiffmbStKal3-etj_hG9OAiHRQfuP3jsPQKXe2DjW9i-KxqXW8oU1fwfeleOcQ</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Kheyrkhah, Hasan</creator><creator>Soltani Zangbar, Hamid</creator><creator>Salimi, Omid</creator><creator>Shahabi, Parviz</creator><creator>Alaei, HojjatAllah</creator><general>John Wiley & Sons, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7TS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5594-5544</orcidid></search><sort><creationdate>20200901</creationdate><title>Prefrontal dopaminergic system and its role in working memory and cognition in spinal cord‐injured rats</title><author>Kheyrkhah, Hasan ; Soltani Zangbar, Hamid ; Salimi, Omid ; Shahabi, Parviz ; Alaei, HojjatAllah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3849-231c9761b3cafd5dd90fde98f9668e32a753a7195c42ed58c319b4f82c125ee73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>cognition</topic><topic>Cognition & reasoning</topic><topic>Cognitive ability</topic><topic>Dopamine</topic><topic>Dopamine receptors</topic><topic>Memory</topic><topic>Paraplegia</topic><topic>Pattern recognition</topic><topic>Prefrontal cortex</topic><topic>Short term memory</topic><topic>Spatial memory</topic><topic>spatial working memory</topic><topic>Spinal cord</topic><topic>Spinal cord injuries</topic><topic>spinal cord injury</topic><topic>Spontaneous alternation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kheyrkhah, Hasan</creatorcontrib><creatorcontrib>Soltani Zangbar, Hamid</creatorcontrib><creatorcontrib>Salimi, Omid</creatorcontrib><creatorcontrib>Shahabi, Parviz</creatorcontrib><creatorcontrib>Alaei, HojjatAllah</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Kheyrkhah, Hasan</au><au>Soltani Zangbar, Hamid</au><au>Salimi, Omid</au><au>Shahabi, Parviz</au><au>Alaei, HojjatAllah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prefrontal dopaminergic system and its role in working memory and cognition in spinal cord‐injured rats</atitle><jtitle>Experimental physiology</jtitle><addtitle>Exp Physiol</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>105</volume><issue>9</issue><spage>1579</spage><epage>1587</epage><pages>1579-1587</pages><issn>0958-0670</issn><eissn>1469-445X</eissn><abstract>New Findings
What is the central question of this study?
How does spinal cord injury affect prefrontal cortex function and the expression of dopamine receptors?
What is the main finding and its importance?
Spinal cord injury impaired cognitive function, which was associated with reduced dopamine receptor expression in the prefrontal cortex.
The effect of spinal cord injury (SCI) has been studied widely in paraplegia and motor areas of the brain, but its mechanisms in memory and cognitive impairment remain controversial. Here, we focused on the impact of SCI on prefrontal performance via dopamine levels and receptors. We divided 18 male rats into three groups, i.e. control, laminectomy and SCI groups. Laminectomy and SCI were induced at T10 of the spinal cord. One week later, after locomotor recovery, the novel object recognition and T‐maze (spontaneous alternation) tests were applied. After behavioural assessments, the rats were killed and their brain tissues harvested. According to the behavioural findings, cognitive function was impaired in the SCI group (P < 0.05). Also, SCI significantly increased the dopamine level and decreased the expression of dopamine receptors in the prefrontal cortex 2 weeks after injury (P < 0.05). Given the role of dopamine in cognition, SCI could impair novel object recognition and spatial working memory via dopaminergic systems.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>32654245</pmid><doi>10.1113/EP088537</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5594-5544</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Wiley Online Library Open Access |
| subjects | cognition Cognition & reasoning Cognitive ability Dopamine Dopamine receptors Memory Paraplegia Pattern recognition Prefrontal cortex Short term memory Spatial memory spatial working memory Spinal cord Spinal cord injuries spinal cord injury Spontaneous alternation |
| title | Prefrontal dopaminergic system and its role in working memory and cognition in spinal cord‐injured rats |
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