Double Trouble: Challenges in the Diagnosis and Management of Ocular Syphilis in HIV-infected Individuals

Syphilis and HIV infection may coexist in the same individual. Ocular syphilis and/or neurosyphilis may develop at any stage of coinfection, with a stronger association between ocular and neurosyphilis in individuals living with HIV, than in HIV-uninfected individuals. The diagnosis of ocular syphil...

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Bibliographic Details
Published in:Ocular immunology and inflammation 2020-10, Vol.28 (7), p.1040-1048
Main Authors: Queiroz, Rafael de Pinho, Smit, Derrick P., Peters, Remco P.H., Vasconcelos-Santos, Daniel Vitor
Format: Article
Language:English
Subjects:
Challenges
diagnosis
HIV
management
ocular syphilis
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Summary:Syphilis and HIV infection may coexist in the same individual. Ocular syphilis and/or neurosyphilis may develop at any stage of coinfection, with a stronger association between ocular and neurosyphilis in individuals living with HIV, than in HIV-uninfected individuals. The diagnosis of ocular syphilis in HIV-infected and -uninfected patients remains with some controversy due to unspecific clinical manifestations and limited diagnostic tests. Penicillin is the mainstay of treatment of ocular syphilis, but alternative options are warranted. This review describes the epidemiology, pathophysiology, and clinical manifestations, as well as the diagnostic and therapeutic challenges posed by ocular syphilis against the background of HIV coinfection.
ISSN:0927-3948
1744-5078
DOI:10.1080/09273948.2020.1772839