Head-to-Head Comparison of the Two MAO-B Radioligands, 18F-THK5351 and 11C-L-Deprenyl, to Visualize Astrogliosis in Patients With Neurological Disorders

ABSTRACTThree patients with neurological disorders (cerebral infarction, progressive multifocal leukoencephalopathy, and multiple sclerosis) underwent F-THK5351 and C-L-deprenyl PET on the same day to visualize lesions undergoing astrogliosis by measuring MAO-B activity. BPND map and SUV image with...

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Bibliographic Details
Published in:Clinical nuclear medicine 2021-01, Vol.46 (1), p.e31-e33
Main Authors: Ishibashi, Kenji, Kameyama, Masashi, Miura, Yoshiharu, Toyohara, Jun, Ishii, Kenji
Format: Article
Language:English
Subjects:
Aminopyridines - metabolism
Carbon Radioisotopes
Female
Gliosis - complications
Gliosis - diagnostic imaging
Gliosis - metabolism
Humans
Ligands
Male
Monoamine Oxidase - metabolism
Nervous System Diseases - complications
Positron-Emission Tomography
Quinolines - metabolism
Selegiline - metabolism
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Summary:ABSTRACTThree patients with neurological disorders (cerebral infarction, progressive multifocal leukoencephalopathy, and multiple sclerosis) underwent F-THK5351 and C-L-deprenyl PET on the same day to visualize lesions undergoing astrogliosis by measuring MAO-B activity. BPND map and SUV image with F-THK5351 as well as Ki map, Ki/K1 map and SUV image with C-L-deprenyl were created. F-THK5351 BPND maps and SUV images clearly identified the lesions undergoing astrogliosis. C-L-deprenyl Ki/K1 maps were close to F-THK5351 images, but very noisy. Ki maps and SUV images were likely affected by the effect of blood flow. Hence, F-THK5351 is superior to C-L-deprenyl for visualizing lesions undergoing astrogliosis.
ISSN:0363-9762
1536-0229
DOI:10.1097/RLU.0000000000003197