Surgical management of pediatric hepatocellular carcinoma: An analysis of the National Cancer Database

This study evaluates overall survival (OS) between liver transplantation (LT) and liver resection (LR), while assessing the effect of margin status, in children with hepatocellular carcinoma (HCC). The National Cancer Database was queried (2004–2015) for children (5 cm were not associated with OS (b...

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Bibliographic Details
Published in:Journal of pediatric surgery 2021-04, Vol.56 (4), p.772-777
Main Authors: Ziogas, Ioannis A., Benedetti, Daniel J., Matsuoka, Lea K., Izzy, Manhal, Rauf, Muhammad A., Pai, Anita K., Bailey, Christina E., Alexopoulos, Sophoclis P.
Format: Article
Language:English
Subjects:
Children
Hepatocellular carcinoma
Liver resection
Liver transplantation
Milan criteria
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Summary:This study evaluates overall survival (OS) between liver transplantation (LT) and liver resection (LR), while assessing the effect of margin status, in children with hepatocellular carcinoma (HCC). The National Cancer Database was queried (2004–2015) for children (5 cm were not associated with OS (both p ≥ 0.42), (iii) when compared to LT, both LR(−) (p = 0.03) and LR(+) (p = 0.001) were associated with increased likelihood of mortality. Although margin-negative resection may be obtained with LT or LR, early LT consultation is warranted for children at high risk of LR(+) regardless of Milan criteria due to the negative impact of LR(+) on OS. Retrospective cohort study. III
ISSN:0022-3468
1531-5037
DOI:10.1016/j.jpedsurg.2020.06.013