The differential diagnostic value of serum HE4 in ovarian disease with elevated CA125; importance of diagnostic added value in clinical practice

For clinical purposes, diagnostic added value of HE4 is important. Diagnostic knowledge is not provided by answering the question, “How accurate is this test?” (test accuracy research). Diagnostic knowledge is the information needed to answer the question, “What is the probability of the presence or...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2020-10, Vol.302 (4), p.1041-1042
Main Author: Sabour, Siamak
Format: Article
Language:English
Subjects:
Accuracy
Clinical medicine
Correspondence
Endocrinology
Gynecology
Human Genetics
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
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Summary:For clinical purposes, diagnostic added value of HE4 is important. Diagnostic knowledge is not provided by answering the question, “How accurate is this test?” (test accuracy research). Diagnostic knowledge is the information needed to answer the question, “What is the probability of the presence or absence of a specific disease given these test results?” (diagnostic accuracy research). Therefore, diagnostic added value of HE4 expression (differences of ROC curves for two diagnostic models with and without HE4) is important in clinical practice. Without assessing reliability, we cannot judge about diagnostic value. The diagnostic value is estimated by two parameters: reliability and accuracy.
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-020-05681-5