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QT interval variability and heart rate turbulence are associated with clinical characteristics in congenital heart disease patients with a systemic right ventricle
•QT interval variability and heart rate turbulence reflect autonomic function.•In patients with a systemic right ventricle, these measures:•Correlated with medication use and with tachy-arrhythmias.•Heart rate turbulence was independently associated with clinical events. QT interval variability (QTV...
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Published in: | Journal of cardiology 2020-11, Vol.76 (5), p.514-520 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | •QT interval variability and heart rate turbulence reflect autonomic function.•In patients with a systemic right ventricle, these measures:•Correlated with medication use and with tachy-arrhythmias.•Heart rate turbulence was independently associated with clinical events.
QT interval variability (QTV) and heart rate turbulence (HRT) are measures of cardiac autonomic function, which, when abnormal, are correlated with ventricular arrhythmias and worse clinical outcome. This study aims to evaluate QTV and HRT in patients with a systemic right ventricle (RV) and to assess correlations with clinical characteristics.
In a retrospective cohort study, QTV and HRT were derived from 24-h Holter registrations of patients with a systemic RV and healthy controls. QTV and HRT were compared between groups. In patients, the association between QTV, HRT, and clinical characteristics was assessed.
Holter recordings from 40 patients (mean age 40 years, 16 females) and 37 healthy controls (mean age 42 years, 21 females) were analyzed. Groups were comparable in terms of age and sex. QTV was increased in patients compared with controls (p |
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ISSN: | 0914-5087 1876-4738 |
DOI: | 10.1016/j.jjcc.2020.05.006 |