Cutting Edge: Batf3 Expression by CD8 T Cells Critically Regulates the Development of Memory Populations

The basic leucine zipper transcription factor ATF-like 3 (BATF3) is required for the development of conventional type 1 dendritic cells that are essential for cross-presentation and CD8 T cell-mediated immunity against intracellular pathogens and tumors. However, whether BATF3 intrinsically regulate...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2020-08, Vol.205 (4), p.901-906
Main Authors: Qiu, Zhijuan, Khairallah, Camille, Romanov, Galina, Sheridan, Brian S
Format: Article
Language:English
Subjects:
Animals
Apoptosis - immunology
Basic-Leucine Zipper Transcription Factors - immunology
Basic-Leucine Zipper Transcription Factors - metabolism
CD8-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - metabolism
Cells, Cultured
Cross-Priming - immunology
Female
Immunity, Cellular - immunology
Immunologic Memory - immunology
Listeria monocytogenes - immunology
Listeriosis - immunology
Listeriosis - metabolism
Male
Mice
Mice, Inbred C57BL
Repressor Proteins - immunology
Repressor Proteins - metabolism
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Summary:The basic leucine zipper transcription factor ATF-like 3 (BATF3) is required for the development of conventional type 1 dendritic cells that are essential for cross-presentation and CD8 T cell-mediated immunity against intracellular pathogens and tumors. However, whether BATF3 intrinsically regulates CD8 T cell responses is not well studied. In this article, we report a role for cell-intrinsic expression in regulating the establishment of circulating and resident memory T cells after foodborne infection of mice. Consistent with other studies, expression by CD8 T cells was dispensable for the primary response. However, T cells underwent increased apoptosis during contraction to contribute to a substantially reduced memory population. memory cells had an impaired ability to mount a robust recall response but remained functional. These findings reveal a cell-intrinsic role of in regulating CD8 T cell memory development.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.2000228