Spontaneous Regression of Laryngeal Squamous Cell Carcinoma After Biopsy

Approximately 7 cases of spontaneous regression of adult laryngeal carcinoma have been published in the literature since 1900. This case presents a 62-year-old male with a 6-month history of hoarseness who was subsequently diagnosed with a T1aN0M0 left true vocal fold squamous cell carcinoma (SCC) a...

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Bibliographic Details
Published in:Ear, nose, & throat journal nose, & throat journal, 2022-01, Vol.101 (1), p.59-61
Main Authors: Watkins, Mariel O., Tate, Alan D., Lewis, James S., Garrett, C. Gaelyn
Format: Article
Language:English
Subjects:
Biopsy
Cancer
Carcinoma, Squamous Cell - pathology
Case reports
Follow-Up Studies
Humans
Immune system
Immunity, Innate
Laryngeal cancer
Laryngeal Neoplasms - pathology
Larynx
Male
Middle Aged
Neoplasm Regression, Spontaneous
Otolaryngology
Pathophysiology
Squamous cell carcinoma
Throat cancer
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Summary:Approximately 7 cases of spontaneous regression of adult laryngeal carcinoma have been published in the literature since 1900. This case presents a 62-year-old male with a 6-month history of hoarseness who was subsequently diagnosed with a T1aN0M0 left true vocal fold squamous cell carcinoma (SCC) after biopsy. One month following the initial biopsy, histopathological findings on repeat biopsy revealed absence of malignancy and regression of the tumor without radiation. There has been no evidence of tumor recurrence. This case exemplifies how innate immune modulation may play a role in the spontaneous regression of laryngeal SCC, although the mechanism remains unknown.
ISSN:0145-5613
1942-7522
DOI:10.1177/0145561320939834