The benefit of complete revascularization after primary PCI for STEMI is attenuated by increasing age: Results from the DANAMI‐3‐PRIMULTI randomized study

Objectives To ascertain the effect of age on outcomes after culprit‐only and complete revascularization after Primary PCI (PPCI) for ST‐elevation myocardial infarction (STEMI). Background The numbers of older patients being treated with PPCI are increasing. The optimal management of nonculprit steno...

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Published in:Catheterization and cardiovascular interventions 2021-03, Vol.97 (4), p.E467-E474
Main Authors: Joshi, Francis R., Lønborg, Jacob, Sadjadieh, Golnaz, Helqvist, Steffen, Holmvang, Lene, Sørensen, Rikke, Jørgensen, Erik, Pedersen, Frants, Tilsted, Hans Henrik, Høfsten, Dan, Køber, Lars, Kelbæk, Henning, Engstrøm, Thomas
Format: Article
Language:English
Subjects:
acute myocardial infarction/STEMI
Age
Arteries
coronary artery disease
Creatinine
elderly patients
Hemoglobin
Implants
Ischemia
Myocardial infarction
primary PCI
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Summary:Objectives To ascertain the effect of age on outcomes after culprit‐only and complete revascularization after Primary PCI (PPCI) for ST‐elevation myocardial infarction (STEMI). Background The numbers of older patients being treated with PPCI are increasing. The optimal management of nonculprit stenoses in such patients is unclear. Methods We conducted an analysis of patients aged ≥75 years randomized in the DANAMI‐3‐PRIMULTI study to either culprit‐only or complete FFR‐guided revascularization. The primary endpoint was a composite of all‐cause mortality, nonfatal reinfarction, and ischaemia‐driven revascularization of lesions in noninfarct‐related arteries after a median of 27 months of follow‐up. Results One hundred and ten of six hundred and twenty seven patients in the DANAMI‐3‐PRIMULTI trial were aged ≥75 years. These patients were more likely female (p 
ISSN:1522-1946
1522-726X
DOI:10.1002/ccd.29131