UPLC-QTOF-MS analysis of cytotoxic and antibacterial extracts of Hechtia glomerata Zucc

, a Mexican medicinal plant employed against bacterial infections and as food, is taxonomically related to the genus which has anticancer activity. Organic and aqueous extracts of leaves were prepared and tested for cytotoxic and antibacterial activity. UPLC-QTOF-MS analysis determined the chemical...

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Bibliographic Details
Published in:Natural product research 2022-01, Vol.36 (2), p.644-648
Main Authors: Stefani, Tommaso, Morales-San Claudio, Pilar Del C, Rios, María Yolanda, Aguilar-Guadarrama, A Berenice, González-Maya, Leticia, Sánchez-Carranza, Jessica Nayelli, González-Ferrara, Maurcio, Camacho-Corona, María Del Rayo
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Mexico
Microbial Sensitivity Tests
Plant Extracts - pharmacology
Plants, Medicinal
Staphylococcus aureus
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Summary:, a Mexican medicinal plant employed against bacterial infections and as food, is taxonomically related to the genus which has anticancer activity. Organic and aqueous extracts of leaves were prepared and tested for cytotoxic and antibacterial activity. UPLC-QTOF-MS analysis determined the chemical composition of active extracts to find cytotoxic and antibacterial compounds. Hexane extract was cytotoxic against HepG2, Hep3B and MCF7 (IC : 24-28 µg/mL), whereas CHCl /MeOH extract against PC3 and MCF7 (IC : 25 and 32 µg/mL). CHCl /MeOH extract showed antibacterial activity against and (MIC: 125 and 62.5 µg/mL). Hexane extract cytotoxic compounds were β-sitosterol, stigmasterol, phytol and ursolic acid. CHCl /MeOH extract antibacterial and/or cytotoxic compounds were daucosterol, oleanolic acid, resveratrol, quercetin, kaempferol, apigenin, cyanidin, -coumaric acid and caffeic acid. This plant could be useful against bacterial infections and cancer. However, studies are needed to determine its toxicity and therapeutic efficacy.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1793148