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UPLC-QTOF-MS analysis of cytotoxic and antibacterial extracts of Hechtia glomerata Zucc
, a Mexican medicinal plant employed against bacterial infections and as food, is taxonomically related to the genus which has anticancer activity. Organic and aqueous extracts of leaves were prepared and tested for cytotoxic and antibacterial activity. UPLC-QTOF-MS analysis determined the chemical...
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| Published in: | Natural product research 2022-01, Vol.36 (2), p.644-648 |
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| Main Authors: | , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c224t-19023459806d65587a47daa8930f8ac06b1cc41a1fe694fc1344e5404621dcf13 |
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| cites | cdi_FETCH-LOGICAL-c224t-19023459806d65587a47daa8930f8ac06b1cc41a1fe694fc1344e5404621dcf13 |
| container_end_page | 648 |
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| container_title | Natural product research |
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| creator | Stefani, Tommaso Morales-San Claudio, Pilar Del C Rios, María Yolanda Aguilar-Guadarrama, A Berenice González-Maya, Leticia Sánchez-Carranza, Jessica Nayelli González-Ferrara, Maurcio Camacho-Corona, María Del Rayo |
| description | , a Mexican medicinal plant employed against bacterial infections and as food, is taxonomically related to the genus
which has anticancer activity. Organic and aqueous extracts of
leaves were prepared and tested for cytotoxic and antibacterial activity. UPLC-QTOF-MS analysis determined the chemical composition of active extracts to find cytotoxic and antibacterial compounds. Hexane extract was cytotoxic against HepG2, Hep3B and MCF7 (IC
: 24-28 µg/mL), whereas CHCl
/MeOH extract against PC3 and MCF7 (IC
: 25 and 32 µg/mL). CHCl
/MeOH extract showed antibacterial activity against
and
(MIC: 125 and 62.5 µg/mL). Hexane extract cytotoxic compounds were β-sitosterol, stigmasterol, phytol and ursolic acid. CHCl
/MeOH extract antibacterial and/or cytotoxic compounds were daucosterol, oleanolic acid, resveratrol, quercetin, kaempferol, apigenin, cyanidin,
-coumaric acid and caffeic acid. This plant could be useful against bacterial infections and cancer. However,
studies are needed to determine its toxicity and therapeutic efficacy. |
| doi_str_mv | 10.1080/14786419.2020.1793148 |
| format | article |
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which has anticancer activity. Organic and aqueous extracts of
leaves were prepared and tested for cytotoxic and antibacterial activity. UPLC-QTOF-MS analysis determined the chemical composition of active extracts to find cytotoxic and antibacterial compounds. Hexane extract was cytotoxic against HepG2, Hep3B and MCF7 (IC
: 24-28 µg/mL), whereas CHCl
/MeOH extract against PC3 and MCF7 (IC
: 25 and 32 µg/mL). CHCl
/MeOH extract showed antibacterial activity against
and
(MIC: 125 and 62.5 µg/mL). Hexane extract cytotoxic compounds were β-sitosterol, stigmasterol, phytol and ursolic acid. CHCl
/MeOH extract antibacterial and/or cytotoxic compounds were daucosterol, oleanolic acid, resveratrol, quercetin, kaempferol, apigenin, cyanidin,
-coumaric acid and caffeic acid. This plant could be useful against bacterial infections and cancer. However,
studies are needed to determine its toxicity and therapeutic efficacy.</description><identifier>ISSN: 1478-6419</identifier><identifier>EISSN: 1478-6427</identifier><identifier>DOI: 10.1080/14786419.2020.1793148</identifier><identifier>PMID: 32674610</identifier><language>eng</language><publisher>England</publisher><subject>Anti-Bacterial Agents - pharmacology ; Mexico ; Microbial Sensitivity Tests ; Plant Extracts - pharmacology ; Plants, Medicinal ; Staphylococcus aureus</subject><ispartof>Natural product research, 2022-01, Vol.36 (2), p.644-648</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c224t-19023459806d65587a47daa8930f8ac06b1cc41a1fe694fc1344e5404621dcf13</citedby><cites>FETCH-LOGICAL-c224t-19023459806d65587a47daa8930f8ac06b1cc41a1fe694fc1344e5404621dcf13</cites><orcidid>0000-0002-4414-6787 ; 0000-0002-8875-8734</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32674610$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stefani, Tommaso</creatorcontrib><creatorcontrib>Morales-San Claudio, Pilar Del C</creatorcontrib><creatorcontrib>Rios, María Yolanda</creatorcontrib><creatorcontrib>Aguilar-Guadarrama, A Berenice</creatorcontrib><creatorcontrib>González-Maya, Leticia</creatorcontrib><creatorcontrib>Sánchez-Carranza, Jessica Nayelli</creatorcontrib><creatorcontrib>González-Ferrara, Maurcio</creatorcontrib><creatorcontrib>Camacho-Corona, María Del Rayo</creatorcontrib><title>UPLC-QTOF-MS analysis of cytotoxic and antibacterial extracts of Hechtia glomerata Zucc</title><title>Natural product research</title><addtitle>Nat Prod Res</addtitle><description>, a Mexican medicinal plant employed against bacterial infections and as food, is taxonomically related to the genus
which has anticancer activity. Organic and aqueous extracts of
leaves were prepared and tested for cytotoxic and antibacterial activity. UPLC-QTOF-MS analysis determined the chemical composition of active extracts to find cytotoxic and antibacterial compounds. Hexane extract was cytotoxic against HepG2, Hep3B and MCF7 (IC
: 24-28 µg/mL), whereas CHCl
/MeOH extract against PC3 and MCF7 (IC
: 25 and 32 µg/mL). CHCl
/MeOH extract showed antibacterial activity against
and
(MIC: 125 and 62.5 µg/mL). Hexane extract cytotoxic compounds were β-sitosterol, stigmasterol, phytol and ursolic acid. CHCl
/MeOH extract antibacterial and/or cytotoxic compounds were daucosterol, oleanolic acid, resveratrol, quercetin, kaempferol, apigenin, cyanidin,
-coumaric acid and caffeic acid. This plant could be useful against bacterial infections and cancer. However,
studies are needed to determine its toxicity and therapeutic efficacy.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Mexico</subject><subject>Microbial Sensitivity Tests</subject><subject>Plant Extracts - pharmacology</subject><subject>Plants, Medicinal</subject><subject>Staphylococcus aureus</subject><issn>1478-6419</issn><issn>1478-6427</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNo9kMFOwzAMhiMEYmPwCKAeuXTEqZM2RzQxhjQ0EJuQuERZmkJRu44klba3p2MbB8v2r9-2_BFyDXQINKN3gGkmEOSQUdZJqUwAsxPS3-mxQJae_tcge-TC-29KGXDOz0kvYSJFAbRP3hcv01H8Op-N4-e3SK90tfWlj5oiMtvQhGZTmk7NuwjlUptgXamryG6C65o_38Sar1Dq6LNqaut00NFHa8wlOSt05e3VIQ_IYvwwH03i6ezxaXQ_jQ1jGGKQlCXIZUZFLjjPUo1prnUmE1pk2lCxBGMQNBRWSCwMJIiWI0XBIDcFJANyu9-7ds1Pa31QdemNrSq9sk3rFUOGUqbd352V763GNd47W6i1K2vttgqo2jFVR6Zqx1QdmHZzN4cT7bK2-f_UEWLyC8G2cDA</recordid><startdate>202201</startdate><enddate>202201</enddate><creator>Stefani, Tommaso</creator><creator>Morales-San Claudio, Pilar Del C</creator><creator>Rios, María Yolanda</creator><creator>Aguilar-Guadarrama, A Berenice</creator><creator>González-Maya, Leticia</creator><creator>Sánchez-Carranza, Jessica Nayelli</creator><creator>González-Ferrara, Maurcio</creator><creator>Camacho-Corona, María Del Rayo</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4414-6787</orcidid><orcidid>https://orcid.org/0000-0002-8875-8734</orcidid></search><sort><creationdate>202201</creationdate><title>UPLC-QTOF-MS analysis of cytotoxic and antibacterial extracts of Hechtia glomerata Zucc</title><author>Stefani, Tommaso ; Morales-San Claudio, Pilar Del C ; Rios, María Yolanda ; Aguilar-Guadarrama, A Berenice ; González-Maya, Leticia ; Sánchez-Carranza, Jessica Nayelli ; González-Ferrara, Maurcio ; Camacho-Corona, María Del Rayo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c224t-19023459806d65587a47daa8930f8ac06b1cc41a1fe694fc1344e5404621dcf13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Mexico</topic><topic>Microbial Sensitivity Tests</topic><topic>Plant Extracts - pharmacology</topic><topic>Plants, Medicinal</topic><topic>Staphylococcus aureus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stefani, Tommaso</creatorcontrib><creatorcontrib>Morales-San Claudio, Pilar Del C</creatorcontrib><creatorcontrib>Rios, María Yolanda</creatorcontrib><creatorcontrib>Aguilar-Guadarrama, A Berenice</creatorcontrib><creatorcontrib>González-Maya, Leticia</creatorcontrib><creatorcontrib>Sánchez-Carranza, Jessica Nayelli</creatorcontrib><creatorcontrib>González-Ferrara, Maurcio</creatorcontrib><creatorcontrib>Camacho-Corona, María Del Rayo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Natural product research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stefani, Tommaso</au><au>Morales-San Claudio, Pilar Del C</au><au>Rios, María Yolanda</au><au>Aguilar-Guadarrama, A Berenice</au><au>González-Maya, Leticia</au><au>Sánchez-Carranza, Jessica Nayelli</au><au>González-Ferrara, Maurcio</au><au>Camacho-Corona, María Del Rayo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>UPLC-QTOF-MS analysis of cytotoxic and antibacterial extracts of Hechtia glomerata Zucc</atitle><jtitle>Natural product research</jtitle><addtitle>Nat Prod Res</addtitle><date>2022-01</date><risdate>2022</risdate><volume>36</volume><issue>2</issue><spage>644</spage><epage>648</epage><pages>644-648</pages><issn>1478-6419</issn><eissn>1478-6427</eissn><abstract>, a Mexican medicinal plant employed against bacterial infections and as food, is taxonomically related to the genus
which has anticancer activity. Organic and aqueous extracts of
leaves were prepared and tested for cytotoxic and antibacterial activity. UPLC-QTOF-MS analysis determined the chemical composition of active extracts to find cytotoxic and antibacterial compounds. Hexane extract was cytotoxic against HepG2, Hep3B and MCF7 (IC
: 24-28 µg/mL), whereas CHCl
/MeOH extract against PC3 and MCF7 (IC
: 25 and 32 µg/mL). CHCl
/MeOH extract showed antibacterial activity against
and
(MIC: 125 and 62.5 µg/mL). Hexane extract cytotoxic compounds were β-sitosterol, stigmasterol, phytol and ursolic acid. CHCl
/MeOH extract antibacterial and/or cytotoxic compounds were daucosterol, oleanolic acid, resveratrol, quercetin, kaempferol, apigenin, cyanidin,
-coumaric acid and caffeic acid. This plant could be useful against bacterial infections and cancer. However,
studies are needed to determine its toxicity and therapeutic efficacy.</abstract><cop>England</cop><pmid>32674610</pmid><doi>10.1080/14786419.2020.1793148</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-4414-6787</orcidid><orcidid>https://orcid.org/0000-0002-8875-8734</orcidid></addata></record> |
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| language | eng |
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| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Science and Technology Collection (Reading list) |
| subjects | Anti-Bacterial Agents - pharmacology Mexico Microbial Sensitivity Tests Plant Extracts - pharmacology Plants, Medicinal Staphylococcus aureus |
| title | UPLC-QTOF-MS analysis of cytotoxic and antibacterial extracts of Hechtia glomerata Zucc |
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