TCONS_00483150 as a novel diagnostic biomarker of systemic lupus erythematosus

We aimed to identify differentially expressed Long noncoding RNAs (lncRNAs) and explore their functional roles in systemic lupus erythematosus (SLE). We identified dysregulated lncRNAs and investigated their prognostic values and potential functions using MiRTarget2, catRAPID omics and Bedtools/blas...

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Bibliographic Details
Published in:Epigenomics 2020-06, Vol.12 (11), p.973-988
Main Authors: Guo, Gangqiang, Chen, Aqiong, Ye, Lele, Wang, Huijing, Chen, Zhiyuan, Yan, Kejing, Shi, Xinyu, Li, Baoqing, Lin, Qiaoai, You, Xiaohan, Jiang, Cizhong, Zhang, Qingfeng, Ding, Xiaokai, Xue, Xiangyang, Zhang, Huidi
Format: Article
Language:English
Subjects:
biomarker
long noncoding RNA
RNA-sequencing
systemic lupus erythematosus
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Summary:We aimed to identify differentially expressed Long noncoding RNAs (lncRNAs) and explore their functional roles in systemic lupus erythematosus (SLE). We identified dysregulated lncRNAs and investigated their prognostic values and potential functions using MiRTarget2, catRAPID omics and Bedtools/blast/Pearson analyses. Among the 143 differentially expressed lncRNAs, TCONS_00483150 could be used to distinguish patients with SLE from healthy controls and those with rheumatoid arthritis and patients with active/stable SLE from healthy controls. TCONS_00483150 was significantly correlated with anti-Rib-P antibody positivity and low C3 levels; TCONS_00483150 dysregulation might contribute to the metabolism of RNA and proteins in SLE patients. Overall, our findings offer a transcriptome-wide overview of aberrantly expressed lncRNAs in patients with SLE and highlight TCONS_00483150 as a potential novel diagnostic biomarker.
ISSN:1750-1911
1750-192X
DOI:10.2217/epi-2019-0265