Pyoderma gangrenosum associated with limited cutaneous systemic sclerosis: a rare case with literature review

Pyoderma gangrenosum (PG) is a skin disease characterized by painful ulcers that, when not appropriately treated, can lead to permanent disfigurement. Pyoderma gangrenosum has been observed in a multitude of autoimmune disorders such as rheumatoid arthritis, inflammatory bowel disease (IBD), and sar...

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Bibliographic Details
Published in:Clinical rheumatology 2021-03, Vol.40 (3), p.1141-1145
Main Authors: Skopis, Maria, Elghawy, Ahmed Aly, Pociurko, Barbara, Oh, Kei Shing, Bag-Ozbek, Ayse
Format: Article
Language:English
Subjects:
Arthritis, Rheumatoid - complications
Autoimmune diseases
Case Based Review
Case reports
Cellulitis
Humans
Inflammatory Bowel Diseases
Intestine
Intravenous administration
Lesions
Literature reviews
Medicine
Medicine & Public Health
Methylprednisolone
Pyoderma
Pyoderma gangrenosum
Pyoderma Gangrenosum - complications
Rheumatoid arthritis
Rheumatology
Sarcoidosis
Scleroderma
Scleroderma, Systemic - complications
Skin diseases
Systemic sclerosis
Ulcers
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Summary:Pyoderma gangrenosum (PG) is a skin disease characterized by painful ulcers that, when not appropriately treated, can lead to permanent disfigurement. Pyoderma gangrenosum has been observed in a multitude of autoimmune disorders such as rheumatoid arthritis, inflammatory bowel disease (IBD), and sarcoidosis (Feld et al. J Rheumatol. 39(1):197, 2012 ; Herrero et al. J Rheumatol. 36:7:1557–1558, 2009 ). It is rarely associated with autoimmune disorders such as systemic sclerosis. We report a case of a patient with known limited cutaneous systemic sclerosis who developed an ulcerated lesion on the 2nd digit of the left hand. The lesion was initially thought to be cellulitis and the patient underwent superficial wound debridement. Postoperatively, the patient’s lesions worsened. The patient was treated with intravenous (IV) methylprednisolone and 0.05% topical clobetasol due to high suspicion for PG with complete resolution of ulcerated lesions and minimal scarring.
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-020-05285-z