Meaningful word acquisition is associated with walking ability over 10 years in Rett syndrome

• Published in: Brain & development (Tokyo. 1979) 2020-11, Vol.42 (10), p.705-712
• Main Authors: Saikusa, Tomoko, Kawaguchi, Machiko, Tanioka (Tetsu T), Tetsuji, Nabatame (Shin N), Shin, Takahashi, Satoru, Yuge, Kotaro, Nagamitsu, Shin-ichiro, Takahashi, Tomoyuki, Yamashita, Yushiro, Kobayashi, Yasuyuki, Hirayama, Chisato, Kakuma, Tatsuyuki, Matsuishi, Toyojiro, Itoh, Masayuki
• Format: Article
• Language: English
• Subjects: Ambulation; Japanese database; Methyl-CpG binding protein 2 mutation; Motor function; Multivariate analysis; Rett syndrome; Univariate analysis
• ISSN: 0387-7604; 1872-7131
• DOI: 10.1016/j.braindev.2020.06.012

To investigate walking ability in Japanese patients with Rett syndrome (RTT). Walking ability was assessed in 100 female Japanese patients with RTT using univariate and multivariate analysis in all age groups, and in patients over 10 years of age. We analyzed walking ability and confounding factors including prenatal-perinatal histories, developmental milestones, somatic and head growth, anthropometric data, body mass index, age of loss of purposeful hand use, age at onset of stereotypic hand movement, history of autistic behavior, age at regression, presence or absence of seizures, and the results of MECP2 genetic examination from the Japanese Rett syndrome database. Univariate analysis revealed that acquisition of walking in all age groups was significantly correlated with the acquisition of meaningful words, microcephaly, and crawling (P