Sucrase Breath Testing in Children Presenting With Chronic Abdominal Pain

• Published in: Clinical pediatrics 2020-11, Vol.59 (13), p.1191-1194
• Main Authors: Rathod, Sandeep, Friesen, Craig A., Radford, Kim, Colombo, Jennifer M.
• Format: Article
• Language: English
• Subjects: Abdomen; Abdominal Pain - etiology; Adolescent; Breath tests; Breath Tests - methods; Carbohydrate Metabolism, Inborn Errors - diagnosis; Carbohydrate Metabolism, Inborn Errors - enzymology; Carbohydrate Metabolism, Inborn Errors - metabolism; Chronic Disease; Chronic pain; Diarrhea; Feasibility Studies; Female; Humans; Male; Pain; Retrospective Studies; Starch; Sucrase - deficiency; Sucrose
• ISSN: 0009-9228; 1938-2707
• DOI: 10.1177/0009922820942183

Sucrase deficiency has been implicated in chronic abdominal pain. Testing for sucrase deficiency generally involves invasive procedures or lengthy clinical visits, but now noninvasive kits that allow home testing are available to test for sucrase deficiency. In order to assess feasibility and utility of at-home testing, we reviewed our experience in 75 consecutive patients. All patients seen in the abdominal pain clinic had histories obtained in a standardized fashion and all had sucrase breath tests completed at home utilizing a commercially available kit. Testing was completed by 46 patients (61.3%). Tests were abnormal indicating sucrase deficiency in 34.8% of those completing testing. No symptoms were predictive of a positive test although there were trends of an association of an abnormal test with diarrhea and bloating. Our findings suggest that sucrase deficiency occurs frequently enough that more widespread testing and/or an empiric trial of sucrose and starch restriction should be considered.