Chiral counter‐current chromatography: A survey of its instrument, mechanism, procedure, and applications

The chiral separation by counter‐current chromatography has made great progress in the past three decades. It has become increasingly popular in the field of chiral separation, and many applications have been introduced during the last years. This review mainly focuses on the current topics, applica...

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Bibliographic Details
Published in:Chirality (New York, N.Y.) N.Y.), 2020-10, Vol.32 (10), p.1264-1283
Main Authors: Duan, Wen‐Da, Huang, Xin‐Yi, Di, Duo‐Long
Format: Article
Language:English
Subjects:
centrifugal partition chromatography
chiral chromatography
chiral separation
Chromatography
counter‐current chromatography
high‐speed counter‐current chromatography
Reviews
Separation
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Summary:The chiral separation by counter‐current chromatography has made great progress in the past three decades. It has become increasingly popular in the field of chiral separation, and many applications have been introduced during the last years. This review mainly focuses on the current topics, applications, and trends in chiral separation by counter‐current chromatography. It contains the development of modern counter‐current chromatography apparatus, theory of counter‐current chromatography, overview of applications of chiral counter‐current chromatography enantioseparation, its current situation, and challenges. At last, some conclusions and perspectives also have been discussed in this review. In chiral CCC separation, the chiral selector which usually dissolved in stationary phase can provide an enantioselective environment in the column.The two isomers will respectively bind chiral selector to form complexes and the isomer‐chiral selector complex shows physical and chemical properties different from original enantiomer. As a result, the racemate could be resolved depending on the differential affinities of levorotatory and dextrorotatory isomers for the chiral selector.
ISSN:0899-0042
1520-636X
DOI:10.1002/chir.23262