Associations between serum L-arginine and ficolins in the early phase of acute ischemic stroke – A pilot study

•The interplay between the L-arginine and the lectin pathway in patients with acute ischemic stroke was investigated here.•Early consumption of ficolin-3 was found to be associated with complications such as post-stroke infection.•The protective role of arginine presumed by improving the cerebral mi...

Full description

Saved in:
Bibliographic Details
Published in:Journal of stroke and cerebrovascular diseases 2020-08, Vol.29 (8), p.104951-104951, Article 104951
Main Authors: Molnar, Tihamer, Csuka, Dorottya, Pusch, Gabriella, Nagy, Lajos, Garred, Peter, Illes, Zsolt
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Arginine - blood
Biomarkers - blood
Brain Ischemia - blood
Brain Ischemia - complications
Brain Ischemia - diagnosis
Brain Ischemia - mortality
Communicable Diseases - blood
Communicable Diseases - etiology
Female
Ficolin
Ficolins
Humans
Infection
Ischemic stroke
L-arginine
Lectins - blood
Male
Mannose- binding lectin
Middle Aged
Outcome
Pilot Projects
Predictive Value of Tests
Prognosis
Risk Factors
Stroke - blood
Stroke - diagnosis
Stroke - mortality
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•The interplay between the L-arginine and the lectin pathway in patients with acute ischemic stroke was investigated here.•Early consumption of ficolin-3 was found to be associated with complications such as post-stroke infection.•The protective role of arginine presumed by improving the cerebral microcirculation in a prothrombotic environment induced by complement activation. Activation of both the L-arginine and the lectin pathway contributes to the pathophysiology and the outcome of acute ischemic stroke (AIS). However, the interplay between the two systems has not yet been examined. A total of 44 patients with AIS were recruited into this study. Serial measurement of serum L-arginine, asymmetric and symmetric dimethylarginine (ADMA, SDMA), and hsCRP, ficolin-2, ficolin-3, MAP-1, MASP-3 and mannose-binding lectin (MBL) were analyzed within 6 h after onset of stroke and 72 h later. Outcomes were assessed as National Institutes of Health Stroke Scale (NIHSS) worsening by 24 h, poststroke infection, and death by 1 month. In the hyperacute stage of AIS, ficolin-3, MAP-1 and MBL were positively correlated with L-arginine within 6 h after onset of symptoms (p
ISSN:1052-3057
1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2020.104951