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Associations between serum L-arginine and ficolins in the early phase of acute ischemic stroke – A pilot study
•The interplay between the L-arginine and the lectin pathway in patients with acute ischemic stroke was investigated here.•Early consumption of ficolin-3 was found to be associated with complications such as post-stroke infection.•The protective role of arginine presumed by improving the cerebral mi...
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| Published in: | Journal of stroke and cerebrovascular diseases 2020-08, Vol.29 (8), p.104951-104951, Article 104951 |
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| container_end_page | 104951 |
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| container_title | Journal of stroke and cerebrovascular diseases |
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| creator | Molnar, Tihamer Csuka, Dorottya Pusch, Gabriella Nagy, Lajos Garred, Peter Illes, Zsolt |
| description | •The interplay between the L-arginine and the lectin pathway in patients with acute ischemic stroke was investigated here.•Early consumption of ficolin-3 was found to be associated with complications such as post-stroke infection.•The protective role of arginine presumed by improving the cerebral microcirculation in a prothrombotic environment induced by complement activation.
Activation of both the L-arginine and the lectin pathway contributes to the pathophysiology and the outcome of acute ischemic stroke (AIS). However, the interplay between the two systems has not yet been examined.
A total of 44 patients with AIS were recruited into this study. Serial measurement of serum L-arginine, asymmetric and symmetric dimethylarginine (ADMA, SDMA), and hsCRP, ficolin-2, ficolin-3, MAP-1, MASP-3 and mannose-binding lectin (MBL) were analyzed within 6 h after onset of stroke and 72 h later. Outcomes were assessed as National Institutes of Health Stroke Scale (NIHSS) worsening by 24 h, poststroke infection, and death by 1 month.
In the hyperacute stage of AIS, ficolin-3, MAP-1 and MBL were positively correlated with L-arginine within 6 h after onset of symptoms (p |
| doi_str_mv | 10.1016/j.jstrokecerebrovasdis.2020.104951 |
| format | article |
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Activation of both the L-arginine and the lectin pathway contributes to the pathophysiology and the outcome of acute ischemic stroke (AIS). However, the interplay between the two systems has not yet been examined.
A total of 44 patients with AIS were recruited into this study. Serial measurement of serum L-arginine, asymmetric and symmetric dimethylarginine (ADMA, SDMA), and hsCRP, ficolin-2, ficolin-3, MAP-1, MASP-3 and mannose-binding lectin (MBL) were analyzed within 6 h after onset of stroke and 72 h later. Outcomes were assessed as National Institutes of Health Stroke Scale (NIHSS) worsening by 24 h, poststroke infection, and death by 1 month.
In the hyperacute stage of AIS, ficolin-3, MAP-1 and MBL were positively correlated with L-arginine within 6 h after onset of symptoms (p<0.05 respectively). Significantly lower ficolin-3 and MASP-3 levels were found at 72 h in patients, who developed post-stroke infection after day 4, when compared to patients without post-stroke infections (p=0.03 and p=0.009). At 72 hours, ficolin-3 levels negatively correlated with S100B (p=0.01). Ficolin-3 at 72 post-stroke hours remained an independent predictor of post-stroke infection, while only hsCRP was an independent predictor of 30-day mortality.
Early consumption of ficolin-3 is associated with complications such as post-stroke infections. In the hyperacute phase of AIS, the positive correlation between ficolins and the NO donor L-arginine may reflect the protective role of L-arginine presumably by improving the cerebral microcirculation in a prothrombotic environment induced by complement activation.</description><identifier>ISSN: 1052-3057</identifier><identifier>EISSN: 1532-8511</identifier><identifier>DOI: 10.1016/j.jstrokecerebrovasdis.2020.104951</identifier><identifier>PMID: 32689592</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Arginine - blood ; Biomarkers - blood ; Brain Ischemia - blood ; Brain Ischemia - complications ; Brain Ischemia - diagnosis ; Brain Ischemia - mortality ; Communicable Diseases - blood ; Communicable Diseases - etiology ; Female ; Ficolin ; Ficolins ; Humans ; Infection ; Ischemic stroke ; L-arginine ; Lectins - blood ; Male ; Mannose- binding lectin ; Middle Aged ; Outcome ; Pilot Projects ; Predictive Value of Tests ; Prognosis ; Risk Factors ; Stroke - blood ; Stroke - diagnosis ; Stroke - mortality ; Time Factors</subject><ispartof>Journal of stroke and cerebrovascular diseases, 2020-08, Vol.29 (8), p.104951-104951, Article 104951</ispartof><rights>2020 The Authors</rights><rights>Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3791-23e29cc989c966ed8f015492877d06ab22a4cd0b644e718b87811fc20e1c32b53</citedby><cites>FETCH-LOGICAL-c3791-23e29cc989c966ed8f015492877d06ab22a4cd0b644e718b87811fc20e1c32b53</cites><orcidid>0000-0003-3610-9852 ; 0000-0002-2876-8586 ; 0000-0002-6149-9787 ; 0000-0001-9655-0450</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32689592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Molnar, Tihamer</creatorcontrib><creatorcontrib>Csuka, Dorottya</creatorcontrib><creatorcontrib>Pusch, Gabriella</creatorcontrib><creatorcontrib>Nagy, Lajos</creatorcontrib><creatorcontrib>Garred, Peter</creatorcontrib><creatorcontrib>Illes, Zsolt</creatorcontrib><title>Associations between serum L-arginine and ficolins in the early phase of acute ischemic stroke – A pilot study</title><title>Journal of stroke and cerebrovascular diseases</title><addtitle>J Stroke Cerebrovasc Dis</addtitle><description>•The interplay between the L-arginine and the lectin pathway in patients with acute ischemic stroke was investigated here.•Early consumption of ficolin-3 was found to be associated with complications such as post-stroke infection.•The protective role of arginine presumed by improving the cerebral microcirculation in a prothrombotic environment induced by complement activation.
Activation of both the L-arginine and the lectin pathway contributes to the pathophysiology and the outcome of acute ischemic stroke (AIS). However, the interplay between the two systems has not yet been examined.
A total of 44 patients with AIS were recruited into this study. Serial measurement of serum L-arginine, asymmetric and symmetric dimethylarginine (ADMA, SDMA), and hsCRP, ficolin-2, ficolin-3, MAP-1, MASP-3 and mannose-binding lectin (MBL) were analyzed within 6 h after onset of stroke and 72 h later. Outcomes were assessed as National Institutes of Health Stroke Scale (NIHSS) worsening by 24 h, poststroke infection, and death by 1 month.
In the hyperacute stage of AIS, ficolin-3, MAP-1 and MBL were positively correlated with L-arginine within 6 h after onset of symptoms (p<0.05 respectively). Significantly lower ficolin-3 and MASP-3 levels were found at 72 h in patients, who developed post-stroke infection after day 4, when compared to patients without post-stroke infections (p=0.03 and p=0.009). At 72 hours, ficolin-3 levels negatively correlated with S100B (p=0.01). Ficolin-3 at 72 post-stroke hours remained an independent predictor of post-stroke infection, while only hsCRP was an independent predictor of 30-day mortality.
Early consumption of ficolin-3 is associated with complications such as post-stroke infections. In the hyperacute phase of AIS, the positive correlation between ficolins and the NO donor L-arginine may reflect the protective role of L-arginine presumably by improving the cerebral microcirculation in a prothrombotic environment induced by complement activation.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arginine - blood</subject><subject>Biomarkers - blood</subject><subject>Brain Ischemia - blood</subject><subject>Brain Ischemia - complications</subject><subject>Brain Ischemia - diagnosis</subject><subject>Brain Ischemia - mortality</subject><subject>Communicable Diseases - blood</subject><subject>Communicable Diseases - etiology</subject><subject>Female</subject><subject>Ficolin</subject><subject>Ficolins</subject><subject>Humans</subject><subject>Infection</subject><subject>Ischemic stroke</subject><subject>L-arginine</subject><subject>Lectins - blood</subject><subject>Male</subject><subject>Mannose- binding lectin</subject><subject>Middle Aged</subject><subject>Outcome</subject><subject>Pilot Projects</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Stroke - blood</subject><subject>Stroke - diagnosis</subject><subject>Stroke - mortality</subject><subject>Time Factors</subject><issn>1052-3057</issn><issn>1532-8511</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqVkMFu1DAQhq0K1JbCKyAfEVIWjxMn9nFbtYC0Ehc4W449Yb0kcbCTVnvjHfqGPAlepXDqhdOMRp_-mfkIeQ9sAwzqD4fNIc0x_ECLEdsY7k1yPm044yegUgLOyCWIkhdSALzIPRO8KJloLsirlA6MAQgpzslFyWuphOKXZNqmFKw3sw9joi3OD4gjTRiXge4KE7_70Y9Izeho523ofab8SOc9UjSxP9JpbxLS0FFjlxmpT3aPg7d0vZT-_vVIt3TyfZjzaHHH1-RlZ_qEb57qFfl2d_v15lOx-_Lx8812V9iyUVDwErmyVkllVV2jkx0DUSkum8ax2rScm8o61tZVhQ3IVjYSoLOcIdiSt6K8Iu_W3CmGnwumWQ_5Nux7M2JYkuYVF4pldZDR6xW1MaQUsdNT9IOJRw1Mn8zrg37OvD6Z16v5HPL2ad_SDuj-RfxVnYHdCmD--t5j1Ml6HC06H9HO2gX_P_v-ABdPpEk</recordid><startdate>202008</startdate><enddate>202008</enddate><creator>Molnar, Tihamer</creator><creator>Csuka, Dorottya</creator><creator>Pusch, Gabriella</creator><creator>Nagy, Lajos</creator><creator>Garred, Peter</creator><creator>Illes, Zsolt</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3610-9852</orcidid><orcidid>https://orcid.org/0000-0002-2876-8586</orcidid><orcidid>https://orcid.org/0000-0002-6149-9787</orcidid><orcidid>https://orcid.org/0000-0001-9655-0450</orcidid></search><sort><creationdate>202008</creationdate><title>Associations between serum L-arginine and ficolins in the early phase of acute ischemic stroke – A pilot study</title><author>Molnar, Tihamer ; Csuka, Dorottya ; Pusch, Gabriella ; Nagy, Lajos ; Garred, Peter ; Illes, Zsolt</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3791-23e29cc989c966ed8f015492877d06ab22a4cd0b644e718b87811fc20e1c32b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arginine - blood</topic><topic>Biomarkers - blood</topic><topic>Brain Ischemia - blood</topic><topic>Brain Ischemia - complications</topic><topic>Brain Ischemia - diagnosis</topic><topic>Brain Ischemia - mortality</topic><topic>Communicable Diseases - blood</topic><topic>Communicable Diseases - etiology</topic><topic>Female</topic><topic>Ficolin</topic><topic>Ficolins</topic><topic>Humans</topic><topic>Infection</topic><topic>Ischemic stroke</topic><topic>L-arginine</topic><topic>Lectins - blood</topic><topic>Male</topic><topic>Mannose- binding lectin</topic><topic>Middle Aged</topic><topic>Outcome</topic><topic>Pilot Projects</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>Stroke - blood</topic><topic>Stroke - diagnosis</topic><topic>Stroke - mortality</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Molnar, Tihamer</creatorcontrib><creatorcontrib>Csuka, Dorottya</creatorcontrib><creatorcontrib>Pusch, Gabriella</creatorcontrib><creatorcontrib>Nagy, Lajos</creatorcontrib><creatorcontrib>Garred, Peter</creatorcontrib><creatorcontrib>Illes, Zsolt</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of stroke and cerebrovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Molnar, Tihamer</au><au>Csuka, Dorottya</au><au>Pusch, Gabriella</au><au>Nagy, Lajos</au><au>Garred, Peter</au><au>Illes, Zsolt</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations between serum L-arginine and ficolins in the early phase of acute ischemic stroke – A pilot study</atitle><jtitle>Journal of stroke and cerebrovascular diseases</jtitle><addtitle>J Stroke Cerebrovasc Dis</addtitle><date>2020-08</date><risdate>2020</risdate><volume>29</volume><issue>8</issue><spage>104951</spage><epage>104951</epage><pages>104951-104951</pages><artnum>104951</artnum><issn>1052-3057</issn><eissn>1532-8511</eissn><abstract>•The interplay between the L-arginine and the lectin pathway in patients with acute ischemic stroke was investigated here.•Early consumption of ficolin-3 was found to be associated with complications such as post-stroke infection.•The protective role of arginine presumed by improving the cerebral microcirculation in a prothrombotic environment induced by complement activation.
Activation of both the L-arginine and the lectin pathway contributes to the pathophysiology and the outcome of acute ischemic stroke (AIS). However, the interplay between the two systems has not yet been examined.
A total of 44 patients with AIS were recruited into this study. Serial measurement of serum L-arginine, asymmetric and symmetric dimethylarginine (ADMA, SDMA), and hsCRP, ficolin-2, ficolin-3, MAP-1, MASP-3 and mannose-binding lectin (MBL) were analyzed within 6 h after onset of stroke and 72 h later. Outcomes were assessed as National Institutes of Health Stroke Scale (NIHSS) worsening by 24 h, poststroke infection, and death by 1 month.
In the hyperacute stage of AIS, ficolin-3, MAP-1 and MBL were positively correlated with L-arginine within 6 h after onset of symptoms (p<0.05 respectively). Significantly lower ficolin-3 and MASP-3 levels were found at 72 h in patients, who developed post-stroke infection after day 4, when compared to patients without post-stroke infections (p=0.03 and p=0.009). At 72 hours, ficolin-3 levels negatively correlated with S100B (p=0.01). Ficolin-3 at 72 post-stroke hours remained an independent predictor of post-stroke infection, while only hsCRP was an independent predictor of 30-day mortality.
Early consumption of ficolin-3 is associated with complications such as post-stroke infections. In the hyperacute phase of AIS, the positive correlation between ficolins and the NO donor L-arginine may reflect the protective role of L-arginine presumably by improving the cerebral microcirculation in a prothrombotic environment induced by complement activation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32689592</pmid><doi>10.1016/j.jstrokecerebrovasdis.2020.104951</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-3610-9852</orcidid><orcidid>https://orcid.org/0000-0002-2876-8586</orcidid><orcidid>https://orcid.org/0000-0002-6149-9787</orcidid><orcidid>https://orcid.org/0000-0001-9655-0450</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Arginine - blood Biomarkers - blood Brain Ischemia - blood Brain Ischemia - complications Brain Ischemia - diagnosis Brain Ischemia - mortality Communicable Diseases - blood Communicable Diseases - etiology Female Ficolin Ficolins Humans Infection Ischemic stroke L-arginine Lectins - blood Male Mannose- binding lectin Middle Aged Outcome Pilot Projects Predictive Value of Tests Prognosis Risk Factors Stroke - blood Stroke - diagnosis Stroke - mortality Time Factors |
| title | Associations between serum L-arginine and ficolins in the early phase of acute ischemic stroke – A pilot study |
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