Assembling patchy plasmonic nanoparticles with aggregation-dependent antibacterial activity

[Display omitted] We realise an antibacterial nanomaterial based on the self-limited assembly of patchy plasmonic colloids, obtained by adsorption of lysozyme to gold nanoparticles. The possibility of selecting the size of the assemblies within several hundred nanometres allows for tuning their opti...

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Bibliographic Details
Published in:Journal of colloid and interface science 2020-11, Vol.580, p.419-428
Main Authors: Brasili, Francesco, Capocefalo, Angela, Palmieri, Damiano, Capitani, Francesco, Chiessi, Ester, Paradossi, Gaio, Bordi, Federico, Domenici, Fabio
Format: Article
Language:English
Subjects:
Antibacterial activity
Functional nanomaterials
Gold nanoparticles
Nanozyme
Patchy colloids
Plasmonics
Protein–nanoparticle interaction
Self-assembly
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Summary:[Display omitted] We realise an antibacterial nanomaterial based on the self-limited assembly of patchy plasmonic colloids, obtained by adsorption of lysozyme to gold nanoparticles. The possibility of selecting the size of the assemblies within several hundred nanometres allows for tuning their optical response in a wide range of frequencies from visible to near infrared. We also demonstrate an aggregation-dependent modulation of the catalytic activity, which results in an enhancement of the antibacterial performances for assemblies of the proper size. The gained overall control on structure, optical properties and biological activity of such nanomaterial paves the way for the development of novel antibacterial nanozymes with promising applications in treating multi drug resistant bacteria.
ISSN:0021-9797
1095-7103
DOI:10.1016/j.jcis.2020.07.006