Progesterone and abnormal uterine bleeding/menstrual disorders

This chapter explores the role of progesterone and progestogens in the management of abnormal uterine bleeding (AUB). Progestogens are used to regulate intermenstrual bleeding and decrease heavy menstrual bleeding (HMB) in women of reproductive age or who are perimenopausal. In menopausal women, pro...

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Bibliographic Details
Published in:Best practice & research. Clinical obstetrics & gynaecology 2020-11, Vol.69, p.62-73
Main Authors: Jewson, Michaela, Purohit, Prashant, Lumsden, Mary Ann
Format: Article
Language:English
Subjects:
HRT
Menopause
Menorrhagia
Progesterone
Progestogen
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Summary:This chapter explores the role of progesterone and progestogens in the management of abnormal uterine bleeding (AUB). Progestogens are used to regulate intermenstrual bleeding and decrease heavy menstrual bleeding (HMB) in women of reproductive age or who are perimenopausal. In menopausal women, progesterones and progestogens prevent endometrial hyperplasia and aim to reduce the development of endometrial cancer. We hope to make clear current best practice including preparation, specific benefits and risks. Progesterone also acts in concert with other hormones to affect breast, cardiovascular system, lipid profile and bone. We hope to explain how its unintended side effects may be used beneficially or may cause intended side effects. •The differing systemic effects of progesterones are useful in progestogen choice.•Progestogens vary in their impact on breast cancer and cardiovascular disease risk.•Abnormal uterine bleeding is usually hormonally managed by progestogens.•Investigation of long-term effect of progestogen-releasing intrauterine systems is needed.
ISSN:1521-6934
1532-1932
DOI:10.1016/j.bpobgyn.2020.05.004