Serum Klotho levels in primary hyperparathyroidism patients before and after parathyroidectomy

Purpose To investigate Klotho level and its association with biochemical indices of primary hyperparathyroidism (PHPT). Methods Fifty PHPT patients and fifty-two age- and body mass index-(BMI) matched healthy control subjects were recruited. In addition, twenty-five PHPT patients underwent parathyro...

Full description

Saved in:
Bibliographic Details
Published in:Endocrine 2020-11, Vol.70 (2), p.421-425
Main Authors: Su, Chi, Meng, Lingqiong, Trooskin, Stanley Z., Shapses, Sue A., He, Yuling, Al-Dayyeni, Aseel, Wang, Xiangbing
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Body mass index
Calcifediol
Calcium
Diabetes
Endocrinology
Etiology
Glucuronidase
Humanities and Social Sciences
Humans
Hyperparathyroidism
Hyperparathyroidism, Primary - surgery
Internal Medicine
Klotho protein
Klotho Proteins
Medicine
Medicine & Public Health
multidisciplinary
Original Article
Parathyroid
Parathyroid Hormone
Parathyroidectomy
Post-menopause
Science
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose To investigate Klotho level and its association with biochemical indices of primary hyperparathyroidism (PHPT). Methods Fifty PHPT patients and fifty-two age- and body mass index-(BMI) matched healthy control subjects were recruited. In addition, twenty-five PHPT patients underwent parathyroidectomy (PTX) and had 4-month follow-up visits. Intact parathyroid hormone (iPTH), 25-hydroxyvitamin D [25(OH)D], calcium, albumin, corrected calcium, and Klotho levels were determined. Results There was no significant difference in age and BMI between PHPT subjects and controls ( p  > 0.05). PHPT patients had Klotho levels (15.4 ± 1.2 ng/mL) about 23% higher compared with those of the controls (11.9 ± 0.8 ng/mL), but this difference was not significant ( p  = 0.063). However, postmenopausal PHPT patients had 45% higher Klotho levels (17.6 ± 1.5 ng/ml) compared with postmenopausal controls (12.1 ± 0.9 ng/mL, p  = 0.008). For postmenopausal subjects, Klotho levels had positive correlation with levels of iPTH ( r  = 0.25, p  = 0.026) and corrected calcium ( r  = 0.34, p  = 0.003), but negative correlation with 25(OH)D ( r  = −0.23, p  = 0.042). After PTX, levels of iPTH and corrected calcium decreased and 25(OH)D levels increased to normal range ( p  
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-020-02427-w