Copper-catalyzed cascade cyclization reaction of 3-aminocyclobutenones with electron-deficient internal alkynes: synthesis of fully substituted indoles

A novel copper-catalyzed cascade cyclization reaction of 3-aminocyclobutenones with electron-deficient internal alkynes has been developed for the first time. This reaction provides a new and highly efficient method for the synthesis of fully substituted indoles by formation of four new bonds and tw...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-09, Vol.56 (68), p.9815-9818
Main Authors: Yu, Yang, Wang, Xin-Yu, Peng, Ju-Yin, Liu, Tao, Zhao, Yu-Long
Format: Article
Language:English
Subjects:
Alkynes
Copper
Crystallography
Indoles
Substitutes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A novel copper-catalyzed cascade cyclization reaction of 3-aminocyclobutenones with electron-deficient internal alkynes has been developed for the first time. This reaction provides a new and highly efficient method for the synthesis of fully substituted indoles by formation of four new bonds and two rings from readily available starting materials in a single step. A novel copper-catalyzed cascade cyclization reaction of 3-aminocyclobutenones with electron-deficient internal alkynes has been developed. This reaction provides a new method for the synthesis of fully substituted indoles by formation of four new bonds and two rings in a single step.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc00512f