Exposure to Moderate Glycosuria Induces Virulence of Group B Streptococcus

Abstract To explore whether glycosuria induces virulence of uropathogens, in turn facilitating urinary tract infection (UTI), we exposed group B Streptococcus (GBS) strain 10/84 to human urine plain or with 300 mg/dL glucose (mimicking moderate glycosuria). Exposure to moderate glycosuria significan...

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Bibliographic Details
Published in:The Journal of infectious diseases 2021-03, Vol.223 (5), p.843-847
Main Authors: John, Preeti P, Baker, Brady C, Paudel, Santosh, Nassour, Lauren, Cagle, Hayden, Kulkarni, Ritwij
Format: Article
Language:English
Subjects:
Animals
Antimicrobial Peptides
Bacteria
Bacterial Adhesion
Cell Line
Diabetes
Disease transmission
Epithelial cells
Glycosuria - complications
Humans
Kidneys
Mice
Mimicry
Pathogens
Streptococcal Infections - microbiology
Streptococcus
Streptococcus agalactiae - genetics
Streptococcus agalactiae - pathogenicity
Streptococcus infections
Surface charge
Urinary tract
Urinary tract infections
Urinary Tract Infections - microbiology
Virulence
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Summary:Abstract To explore whether glycosuria induces virulence of uropathogens, in turn facilitating urinary tract infection (UTI), we exposed group B Streptococcus (GBS) strain 10/84 to human urine plain or with 300 mg/dL glucose (mimicking moderate glycosuria). Exposure to moderate glycosuria significantly augmented bacterial growth, kidney bacterial burden in a mouse model of ascending UTI, and virulence characteristics and expression of corresponding genes. Exposure to glycosuria increased GBS adherence to human bladder epithelial cell line and expression of corresponding PI2a fimbrial gene, antimicrobial peptide LL-37 resistance and bacterial surface charge modulating dltA, and GBS hemolytic ability and expression of genes encoding pore-forming toxins.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiaa443