COVID-19 - Recent advancements in identifying novel vaccine candidates and current status of upcoming SARS-CoV-2 vaccines

The COVID-19 pandemic caused by SARS-CoV-2 has spread rapidly. To date, countries have relied on the prevention of the disease through isolation, quarantine, and clinical care of affected individuals. However, studies on the roles of asymptomatic and mildly infected subjects in disease transmission,...

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Bibliographic Details
Published in:Human vaccines & immunotherapeutics 2020-12, Vol.16 (12), p.2891-2904
Main Authors: Iqbal Yatoo, Mohd, Hamid, Zeenat, Parray, Oveas Rafiq, Wani, Aasim Habib, Ul Haq, Abrar, Saxena, Archana, Patel, Shailesh Kumar, Pathak, Mamta, Tiwari, Ruchi, Malik, Yashpal Singh, Sah, Ranjit, Rabaan, Ali A., Rodriguez Morales, Alfonso J., Dhama, Kuldeep
Format: Article
Language:English
Subjects:
COVID-19
COVID-19 - immunology
COVID-19 - metabolism
COVID-19 - prevention & control
COVID-19 - therapy
COVID-19 Vaccines - immunology
COVID-19 Vaccines - metabolism
COVID-19 Vaccines - therapeutic use
Humans
Immunization, Passive
pandemic
Review
SARS-CoV-2
SARS-CoV-2 - drug effects
SARS-CoV-2 - immunology
SARS-CoV-2 - metabolism
vaccines
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Summary:The COVID-19 pandemic caused by SARS-CoV-2 has spread rapidly. To date, countries have relied on the prevention of the disease through isolation, quarantine, and clinical care of affected individuals. However, studies on the roles of asymptomatic and mildly infected subjects in disease transmission, use of antiviral drugs, and vaccination of the general population will be very important for mitigating the effects of the eventual return of this pandemic. Initial investigations are ongoing to evaluate antigenic structures of SARS-CoV-2 and the immunogenicity of vaccine candidates. There also is a need to comprehensively compile the details of previous studies on SARS-related vaccines that can be extrapolated to identify potent vaccine targets for developing COVID-19 vaccines. This review aims to analyze previous studies, current status, and future possibilities for producing SARS-CoV-2 vaccines.
ISSN:2164-5515
2164-554X
DOI:10.1080/21645515.2020.1788310