Complications of accelerated corneal collagen cross-linking: review of 2025 eyes

Purpose To evaluate the early- and late-stage complications of accelerated cross-linking (A-CXL) in a large case series and investigate the relationship of A-CXL complications with ocular and systemic conditions accompanying keratoconus. Methods Retrospectively, records of 2025 eyes of 1184 patients...

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Bibliographic Details
Published in:International ophthalmology 2020-12, Vol.40 (12), p.3269-3277
Main Authors: Çakmak, Semih, Sucu, Mehmet Emin, Yildirim, Yusuf, Kepez Yildiz, Burcin, Kirgiz, Ahmet, Bektaşoğlu, Damla Leman, Demirok, Ahmet
Format: Article
Language:English
Subjects:
Allergic diseases
Collagen
Complications
Cornea
Cross-linking
Crosslinking
Down syndrome
Down's syndrome
Eye (anatomy)
Healing
Health services
Keratoconjunctivitis
Keratoconus
Medical treatment
Medicine
Medicine & Public Health
Ophthalmology
Original Paper
Statistical analysis
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Summary:Purpose To evaluate the early- and late-stage complications of accelerated cross-linking (A-CXL) in a large case series and investigate the relationship of A-CXL complications with ocular and systemic conditions accompanying keratoconus. Methods Retrospectively, records of 2025 eyes of 1184 patients diagnosed with keratoconus between March 2013 and 2020 who underwent A-CXL (18 mW/cm 2 for 5 min) treatment were reviewed. Comorbid ocular and systemic diseases other than keratoconus were recorded. In the postoperative follow-up, early and late complications and their association with accompanying diseases were examined. Results The mean age of patients was 26.16 ± 6.05 (range 18–42), and the mean follow-up time was 3.40 ± 1.63 years (range 1–8 years). Vernal keratoconjunctivitis (3.7%) was the most common disease accompanying keratoconus. Less frequently, systemic allergic diseases (2.9%) and Down syndrome (2.3%) were observed. The most common complication in the early postoperative period was haze formation (9.1%), while failure of the treatment (4.2%) occurred in the late period. Other common complications were loss of two or more Snellen lines (2.4%) and delayed epithelial healing (1.8%). There was a significant relationship between vernal keratoconjunctivitis and delayed epithelial healing ( p  = 0.011). Statistically significant relationships were found between Down syndrome and haze formation ( p  
ISSN:0165-5701
1573-2630
DOI:10.1007/s10792-020-01512-3