Estrogen enhances browning in adipose tissue by M2 macrophage polarization via heme oxygenase‐1

Loss of ovarian function results in increased fat mass, leading to the accumulation of adipose tissue macrophages that participate in chronic inflammation. We hypothesized that ovariectomy (OVX)‐induced increases in body weight and fat mass are associated with decreased adipose tissue (AT) browning...

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Bibliographic Details
Published in:Journal of cellular physiology 2021-03, Vol.236 (3), p.1875-1888
Main Authors: Sul, Ok‐Joo, Hyun, Hyo‐Jung, Rajasekaran, Monisha, Suh, Jae‐Hee, Choi, Hye‐Seon
Format: Article
Language:English
Subjects:
Adipose tissue
Adipose Tissue, Brown - metabolism
Animals
Bioaccumulation
Body fat
Body weight
Browning
Cell Polarity - drug effects
estrogen
Estrogens
Estrogens - pharmacology
Female
Heme
Heme Oxygenase-1 - metabolism
heme oxygenase‐1
Lipids
M2 polarization
Macrophages
Macrophages - cytology
Macrophages - drug effects
Macrophages - enzymology
Mice
Mice, Inbred C57BL
Models, Biological
Ovariectomy
Oxygenase
Polarization
Reactive oxygen species
Reactive Oxygen Species - metabolism
Reproductive status
Surgery
Up-Regulation - drug effects
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Summary:Loss of ovarian function results in increased fat mass, leading to the accumulation of adipose tissue macrophages that participate in chronic inflammation. We hypothesized that ovariectomy (OVX)‐induced increases in body weight and fat mass are associated with decreased adipose tissue (AT) browning due to estrogen (E2) deficiency. In mice, OVX decreased AT browning along with increased body weight, fat mass, and size of lipid droplets 12 weeks after surgery. Exogenous E2 recovered the OVX‐induced changes. AT browning was enhanced by M2 macrophages induced by exogenous E2. E2‐induced M2 polarization occurred due to the increased expression of heme oxygenase‐1 (HO‐1) in macrophages, leading to decreased reactive oxygen species levels. Collectively, we demonstrated that E2 enhances AT browning via M2 polarization mediated by HO‐1. Loss of ovarian function decreases adipose tissue browning via M1 polarization, resulting in increases of body weight and fat mass, whereas estrogen increases it via M2 polarization mediated by heme oxygenase‐1 that reduces reactive oxygen species, leading to decreases of body weight and fat mass.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.29971