A general strategy for degradable single-chain nanoparticles via cross-linker mediated chain collapse of radical copolymers

Radical ring-opening copolymerization (rROP) between 2-methylene-1,3-dioxepane (MDO) and methacrylic acid N -hydroxysuccinimide ester (NHSMA) furnishes a reactive polyester-based linear copolymer precursor. Subsequent cross-linker mediated chain collapse affords degradable single-chain nanoparticles...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-09, Vol.56 (68), p.9838-9841
Main Authors: Jackson, Alexander W., Chennamaneni, Lohitha Rao, Mothe, Srinivasa Reddy, Thoniyot, Praveen
Format: Article
Language:English
Subjects:
Copolymerization
Copolymers
Crosslinking
Degradation
Methacrylic acid
Nanoparticles
Ring opening polymerization
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Summary:Radical ring-opening copolymerization (rROP) between 2-methylene-1,3-dioxepane (MDO) and methacrylic acid N -hydroxysuccinimide ester (NHSMA) furnishes a reactive polyester-based linear copolymer precursor. Subsequent cross-linker mediated chain collapse affords degradable single-chain nanoparticles (DSCNPs). This methodology is an experimentally robust and straightforward route to main-chain degradable polymeric nanoparticles in the sub-30 nm size range.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc03792c