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A general strategy for degradable single-chain nanoparticles via cross-linker mediated chain collapse of radical copolymers
Radical ring-opening copolymerization (rROP) between 2-methylene-1,3-dioxepane (MDO) and methacrylic acid N -hydroxysuccinimide ester (NHSMA) furnishes a reactive polyester-based linear copolymer precursor. Subsequent cross-linker mediated chain collapse affords degradable single-chain nanoparticles...
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Published in: | Chemical communications (Cambridge, England) England), 2020-09, Vol.56 (68), p.9838-9841 |
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container_title | Chemical communications (Cambridge, England) |
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creator | Jackson, Alexander W. Chennamaneni, Lohitha Rao Mothe, Srinivasa Reddy Thoniyot, Praveen |
description | Radical ring-opening copolymerization (rROP) between 2-methylene-1,3-dioxepane (MDO) and methacrylic acid
N
-hydroxysuccinimide ester (NHSMA) furnishes a reactive polyester-based linear copolymer precursor. Subsequent cross-linker mediated chain collapse affords degradable single-chain nanoparticles (DSCNPs). This methodology is an experimentally robust and straightforward route to main-chain degradable polymeric nanoparticles in the sub-30 nm size range. |
doi_str_mv | 10.1039/d0cc03792c |
format | article |
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-hydroxysuccinimide ester (NHSMA) furnishes a reactive polyester-based linear copolymer precursor. Subsequent cross-linker mediated chain collapse affords degradable single-chain nanoparticles (DSCNPs). This methodology is an experimentally robust and straightforward route to main-chain degradable polymeric nanoparticles in the sub-30 nm size range.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/d0cc03792c</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Copolymerization ; Copolymers ; Crosslinking ; Degradation ; Methacrylic acid ; Nanoparticles ; Ring opening polymerization</subject><ispartof>Chemical communications (Cambridge, England), 2020-09, Vol.56 (68), p.9838-9841</ispartof><rights>Copyright Royal Society of Chemistry 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c292t-8a949dd72449d3846bf0cd269effed3dac6e95c4ab32b63550f781ffb2ad8cb33</citedby><cites>FETCH-LOGICAL-c292t-8a949dd72449d3846bf0cd269effed3dac6e95c4ab32b63550f781ffb2ad8cb33</cites><orcidid>0000-0001-6618-7654 ; 0000-0001-5062-1831 ; 0000-0001-8474-0193 ; 0000-0001-6415-3311</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Jackson, Alexander W.</creatorcontrib><creatorcontrib>Chennamaneni, Lohitha Rao</creatorcontrib><creatorcontrib>Mothe, Srinivasa Reddy</creatorcontrib><creatorcontrib>Thoniyot, Praveen</creatorcontrib><title>A general strategy for degradable single-chain nanoparticles via cross-linker mediated chain collapse of radical copolymers</title><title>Chemical communications (Cambridge, England)</title><description>Radical ring-opening copolymerization (rROP) between 2-methylene-1,3-dioxepane (MDO) and methacrylic acid
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-hydroxysuccinimide ester (NHSMA) furnishes a reactive polyester-based linear copolymer precursor. Subsequent cross-linker mediated chain collapse affords degradable single-chain nanoparticles (DSCNPs). This methodology is an experimentally robust and straightforward route to main-chain degradable polymeric nanoparticles in the sub-30 nm size range.</description><subject>Copolymerization</subject><subject>Copolymers</subject><subject>Crosslinking</subject><subject>Degradation</subject><subject>Methacrylic acid</subject><subject>Nanoparticles</subject><subject>Ring opening polymerization</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpdkU9LxDAQxYsouK5e_AQBLyJU06RJ06PUv7DgRcFbSZNJzZptatIVFr-82V1PzuXN4cebN7wsOy_wdYFpfaOxUphWNVEH2aygvMxZKd4Ptzur84qW7Dg7iXGJ0xRMzLKfW9TDAEE6FKcgJ-g3yPiANPRBatk5QNEOvYNcfUg7oEEOfpRhsspBRN9WIhV8jLmzwycEtAJtk4lGe1p55-QYAXmDkp1V6Yzyo3ebFYR4mh0Z6SKc_ek8e3u4f22e8sXL43Nzu8gVqcmUC1mXtdYVKZNQUfLOYKUJr8EY0FRLxaFmqpQdJR2njGFTicKYjkgtVEfpPLvc-47Bf60hTu3KRgUp2gB-HVtSkooRyiuR0It_6NKvw5DSJYpywRkpeKKu9tTu9wCmHYNdybBpC9xue2jvcNPsemjoL6jGfVc</recordid><startdate>20200904</startdate><enddate>20200904</enddate><creator>Jackson, Alexander W.</creator><creator>Chennamaneni, Lohitha Rao</creator><creator>Mothe, Srinivasa Reddy</creator><creator>Thoniyot, Praveen</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6618-7654</orcidid><orcidid>https://orcid.org/0000-0001-5062-1831</orcidid><orcidid>https://orcid.org/0000-0001-8474-0193</orcidid><orcidid>https://orcid.org/0000-0001-6415-3311</orcidid></search><sort><creationdate>20200904</creationdate><title>A general strategy for degradable single-chain nanoparticles via cross-linker mediated chain collapse of radical copolymers</title><author>Jackson, Alexander W. ; Chennamaneni, Lohitha Rao ; Mothe, Srinivasa Reddy ; Thoniyot, Praveen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c292t-8a949dd72449d3846bf0cd269effed3dac6e95c4ab32b63550f781ffb2ad8cb33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Copolymerization</topic><topic>Copolymers</topic><topic>Crosslinking</topic><topic>Degradation</topic><topic>Methacrylic acid</topic><topic>Nanoparticles</topic><topic>Ring opening polymerization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jackson, Alexander W.</creatorcontrib><creatorcontrib>Chennamaneni, Lohitha Rao</creatorcontrib><creatorcontrib>Mothe, Srinivasa Reddy</creatorcontrib><creatorcontrib>Thoniyot, Praveen</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jackson, Alexander W.</au><au>Chennamaneni, Lohitha Rao</au><au>Mothe, Srinivasa Reddy</au><au>Thoniyot, Praveen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A general strategy for degradable single-chain nanoparticles via cross-linker mediated chain collapse of radical copolymers</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><date>2020-09-04</date><risdate>2020</risdate><volume>56</volume><issue>68</issue><spage>9838</spage><epage>9841</epage><pages>9838-9841</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>Radical ring-opening copolymerization (rROP) between 2-methylene-1,3-dioxepane (MDO) and methacrylic acid
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-hydroxysuccinimide ester (NHSMA) furnishes a reactive polyester-based linear copolymer precursor. Subsequent cross-linker mediated chain collapse affords degradable single-chain nanoparticles (DSCNPs). This methodology is an experimentally robust and straightforward route to main-chain degradable polymeric nanoparticles in the sub-30 nm size range.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/d0cc03792c</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-6618-7654</orcidid><orcidid>https://orcid.org/0000-0001-5062-1831</orcidid><orcidid>https://orcid.org/0000-0001-8474-0193</orcidid><orcidid>https://orcid.org/0000-0001-6415-3311</orcidid></addata></record> |
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subjects | Copolymerization Copolymers Crosslinking Degradation Methacrylic acid Nanoparticles Ring opening polymerization |
title | A general strategy for degradable single-chain nanoparticles via cross-linker mediated chain collapse of radical copolymers |
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