Troublesome friends within us: the role of gut microbiota on rheumatoid arthritis etiopathogenesis and its clinical and therapeutic relevance

The role of gut microbiota on immune regulation and the development of autoimmune diseases such as rheumatoid arthritis (RA) is an emerging research topic. Multiple studies have demonstrated alterations on gut microbiota composition and/or function (referred to as dysbiosis) both in early and establ...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and experimental medicine 2021-02, Vol.21 (1), p.1-13
Main Authors: Reyes-Castillo, Zyanya, Valdés-Miramontes, Elia, Llamas-Covarrubias, Mara, Muñoz-Valle, J. Francisco
Format: Article
Language:English
Subjects:
Autoimmune diseases
Digestive system
Dysbacteriosis
Epitopes
Gastrointestinal tract
Hematology
Immune system
Immunological tolerance
Immunoregulation
Inflammation
Internal Medicine
Intestinal microflora
Intestine
Medicine
Medicine & Public Health
Microbiota
Mimicry
Molecular modelling
Oncology
Permeability
Phenotypes
Post-translation
Review Article
Rheumatoid arthritis
Termites
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The role of gut microbiota on immune regulation and the development of autoimmune diseases such as rheumatoid arthritis (RA) is an emerging research topic. Multiple studies have demonstrated alterations on gut microbiota composition and/or function (referred to as dysbiosis) both in early and established RA patients. Still, research delineating the molecular mechanisms by which gut microorganisms induce the loss of immune tolerance or contribute to disease progression is scarce. Available data indicate that gut microbiota alterations are involved in RA autoimmune response by several mechanisms including the post-translational modification of host proteins, molecular mimicry between bacterial and host epitopes, activation of immune system and polarization toward inflammatory phenotypes, as well as induction of intestinal permeability. Therefore, in this review we analyze recent clinical and molecular evidence linking gut microbiota with the etiopathogenesis of RA. The potential of the gut microbiota as a diagnostic or severity biomarker is discussed, as well as the opportunity areas for the development of complementary therapeutic strategies based on the modulation of gut microbiota in the rheumatic patient.
ISSN:1591-8890
1591-9528
DOI:10.1007/s10238-020-00647-y