Eye movements in anorexia nervosa: State or trait markers?

• Published in: The International journal of eating disorders 2020-10, Vol.53 (10), p.1678-1684
• Main Authors: Phillipou, Andrea, Abel, Larry A., Gurvich, Caroline, Castle, David J., Rossell, Susan L.
• Format: Article
• Language: English
• Subjects: Adult; Anorexia; anorexia nervosa; Anorexia Nervosa - complications; Eating disorders; Eye movements; eye tracking; Female; Humans; Male; memory‐guided saccades; saccade; Saccades - physiology; scan path; superior colliculus; Young Adult
• ISSN: 0276-3478; 1098-108X
• DOI: 10.1002/eat.23345

Objective Differences in saccadic eye movements are widely reported in mental illnesses, and can indirectly inform our understanding of neurobiological and cognitive underpinnings of psychiatric conditions, including anorexia nervosa (AN). Preliminary research has suggested that individuals with AN may show specific eye movement abnormalities; whether these deficits are representative of state or trait effects is, however, unclear. The aim of this study was to identify whether there are demonstrable differences in performance on saccadic eye movement tasks in individuals with current AN (c‐AN), those who are weight‐restored from AN (wr‐AN), biological sisters of individuals with AN (AN‐sis), and healthy controls (HC). Methods Eighty participants took part in the study (n = 20/group). A set of saccadic eye movement tasks was administered, including prosaccade, antisaccade, memory‐guided saccade, and visual scanpath tasks. Results The c‐AN group showed an increased rate of inhibitory errors to 10° targets on the memory‐guided saccade task. Discussion The results are discussed in terms of the potential role of the superior colliculus in AN, and that the findings may reflect a state measure of AN.