A new cycloartane triterpene and other phytoconstituents from the aerial parts of Euphorbia dendroides

New cycloartane-type triterpene 23 R/S-3β-hydroxycycloart-24-ene-23-methyl ether 1a,b (as an C-23 epimeric mixture), along with ten known compounds, including 1 steroid, 3 fatty acids and 6 triterpenoids were isolated from the aerial parts of Euphorbia dendroides L. (Euphorbiaceae). The known compou...

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Published in:Natural product research 2022-02, Vol.36 (3), p.828-836
Main Authors: Hassan, Ahmed R., Ashour, Ahmed, Amen, Yhiya, Nagata, Maki, El-Toumy, Sayed A., Shimizu, Kuniyoshi
Format: Article
Language:English
Subjects:
cycloartanes
cytotoxic activity
Euphorbia
Euphorbia dendroides
Euphorbiaceae
HeLa Cells
Humans
Molecular Structure
Plant Components, Aerial
Triterpenes - pharmacology
triterpenoids
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container_title Natural product research
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creator Hassan, Ahmed R.
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Nagata, Maki
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Shimizu, Kuniyoshi
description New cycloartane-type triterpene 23 R/S-3β-hydroxycycloart-24-ene-23-methyl ether 1a,b (as an C-23 epimeric mixture), along with ten known compounds, including 1 steroid, 3 fatty acids and 6 triterpenoids were isolated from the aerial parts of Euphorbia dendroides L. (Euphorbiaceae). The known compounds (2-11) were identified using 1 D & 2 D-NMR spectra and by comparison with data reported in the literature as well as using GC-MS for the isolated fatty acids. The new compound 1 (a,b) was elucidated by comprehensive 1 D & 2 D NMR experiments as well as LR & HR-FAB-MS. In addition, the isolated cycloartane-type triterpenoids have been tested for in vitro cytotoxicity against different cell lines. The new compound 1 (a,b) exhibited good to weak selective cytotoxic activities against HepG2, Huh-7, KLM-1, 1321N1 and HeLa cell lines with IC 50 values of 20.67 ± 0.72, 16.24 ± 0.53, 22.59 ± 0.94, 25.99 ± 0.31 and 40.50 ± 3.14 μM, respectively.
doi_str_mv 10.1080/14786419.2020.1800693
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subjects cycloartanes
cytotoxic activity
Euphorbia
Euphorbia dendroides
Euphorbiaceae
HeLa Cells
Humans
Molecular Structure
Plant Components, Aerial
Triterpenes - pharmacology
triterpenoids
title A new cycloartane triterpene and other phytoconstituents from the aerial parts of Euphorbia dendroides
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