Ginseng Seed Oil Inhibits the Growth of Estrogen Receptor-positive Breast Cancer Cells

Background/Aim: Although ginseng seed oil (GSO) appears to have various roles in the body, its anti-cancer effect has not been investigated. Tamoxifen is widely used to treat estrogen receptor-positive (ER+) breast cancer but shows adverse effects with drug resistance. This study investigated the ef...

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Bibliographic Details
Published in:Anticancer research 2020-08, Vol.40 (8), p.4529-4535
Main Authors: KIM, TAE HUN, KWON, SANG-CHUL, KIM, JEONG NAM, YOON, JI-HYE, CHO, SUNG-GOOK
Format: Article
Language:English
Subjects:
Annexin V
Anticancer properties
Apoptosis
Breast cancer
Cell growth
Cell viability
Drug resistance
Estrogen receptors
Estrogens
Ginseng
Oils & fats
Oleic acid
Receptors
Synergistic effect
Tamoxifen
Western blotting
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Summary:Background/Aim: Although ginseng seed oil (GSO) appears to have various roles in the body, its anti-cancer effect has not been investigated. Tamoxifen is widely used to treat estrogen receptor-positive (ER+) breast cancer but shows adverse effects with drug resistance. This study investigated the effect of GSO in ER+ breast cancer cell growth. Materials and Methods: Cell viability assays, western blots and Annexin V staining were conducted to examine cell viability and apoptosis. The synergistic effect of tamoxifen in combination with GSO or oleic acid (OA) was determined. Results: GSO and OA caused apoptosis of MCF-7 ER+ breast cancer cells and had synergistic effects with tamoxifen in inhibiting tamoxifen-resistant MCF-7 (MCF-7TAMR) ER+ breast cancer cell growth. Conclusion: GSO may block ER+ breast cancer recurrence in combination with tamoxifen.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.14458