Ginseng Seed Oil Inhibits the Growth of Estrogen Receptor-positive Breast Cancer Cells

Background/Aim: Although ginseng seed oil (GSO) appears to have various roles in the body, its anti-cancer effect has not been investigated. Tamoxifen is widely used to treat estrogen receptor-positive (ER+) breast cancer but shows adverse effects with drug resistance. This study investigated the ef...

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Published in:Anticancer research 2020-08, Vol.40 (8), p.4529-4535
Main Authors: KIM, TAE HUN, KWON, SANG-CHUL, KIM, JEONG NAM, YOON, JI-HYE, CHO, SUNG-GOOK
Format: Article
Language:English
Subjects:
Annexin V
Anticancer properties
Apoptosis
Breast cancer
Cell growth
Cell viability
Drug resistance
Estrogen receptors
Estrogens
Ginseng
Oils & fats
Oleic acid
Receptors
Synergistic effect
Tamoxifen
Western blotting
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container_end_page 4535
container_issue 8
container_start_page 4529
container_title Anticancer research
container_volume 40
creator KIM, TAE HUN
KWON, SANG-CHUL
KIM, JEONG NAM
YOON, JI-HYE
CHO, SUNG-GOOK
description Background/Aim: Although ginseng seed oil (GSO) appears to have various roles in the body, its anti-cancer effect has not been investigated. Tamoxifen is widely used to treat estrogen receptor-positive (ER+) breast cancer but shows adverse effects with drug resistance. This study investigated the effect of GSO in ER+ breast cancer cell growth. Materials and Methods: Cell viability assays, western blots and Annexin V staining were conducted to examine cell viability and apoptosis. The synergistic effect of tamoxifen in combination with GSO or oleic acid (OA) was determined. Results: GSO and OA caused apoptosis of MCF-7 ER+ breast cancer cells and had synergistic effects with tamoxifen in inhibiting tamoxifen-resistant MCF-7 (MCF-7TAMR) ER+ breast cancer cell growth. Conclusion: GSO may block ER+ breast cancer recurrence in combination with tamoxifen.
doi_str_mv 10.21873/anticanres.14458
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subjects Annexin V
Anticancer properties
Apoptosis
Breast cancer
Cell growth
Cell viability
Drug resistance
Estrogen receptors
Estrogens
Ginseng
Oils & fats
Oleic acid
Receptors
Synergistic effect
Tamoxifen
Western blotting
title Ginseng Seed Oil Inhibits the Growth of Estrogen Receptor-positive Breast Cancer Cells
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